Last reviewed 2026-06-01 · How we verify

aloevera gel

aloevera gel is a Herbal/botanical topical agent Small molecule drug developed by The Oxford Dental College, Hospital and Research Center, Bangalore, India. It is currently FDA-approved for Wound healing and tissue repair, Minor burns and scalds, Oral mucositis and dental wound care. Also known as: AV.

Aloe vera gel provides topical wound healing and anti-inflammatory effects through polysaccharides, anthraquinones, and other bioactive compounds that promote tissue repair and reduce inflammation.

Aloe vera gel has been studied as a potential treatment for several conditions, including radiation dermatitis, radiation-induced oral mucositis, oral submucous fibrosis, and chronic periodontitis. The exact mechanism of aloe vera gel is unknown, but it has been compared to Gelronate gel in clinical trials for preventing or minimizing radiation-induced dermatitis in breast cancer patients.

At a glance

Mechanism of action

Aloe vera contains multiple active constituents including acemannan (a polysaccharide), aloin, and various amino acids that stimulate fibroblast activity, enhance collagen synthesis, and promote epithelialization. The gel also exhibits antimicrobial and anti-inflammatory properties that reduce bacterial colonization and inflammatory cytokine production at wound sites, facilitating faster healing and tissue regeneration.

Approved indications

• Wound healing and tissue repair
• Minor burns and scalds
• Oral mucositis and dental wound care

Common side effects

• Contact dermatitis or local irritation
• Allergic reaction

Key clinical trials

• Comparison Between the Effect of Aloe Vera and Benzydamine Hydrochloride Mouth Gel on Prevention of Pain and Progression of Radiation-induced Oral Mucositis (PHASE1, PHASE2)
• Comparing Aloe Vera Gel and Rosemary Oil in Pressure Injury Prevention (NA)
• Use of Gelronate Gel vs. Aloevera in Preventing/Minimizing Radiation-induced Dermatitis in Breast Cancer Patients (NA)
• Local Host Modulating Agents Alendronate & Aloe Vera for Treatment of Furcation Defects in Chronic Periodontitis (PHASE2, PHASE3)
• Locally Delivered Metformin and Aloe Vera for Treatment of Intrabody Defects in Chronic Periodontitis (PHASE2, PHASE3)
• Efficacy of AloeVera Gel Gum Massaging and Adjunct to Scaling and Root Planing in Chronic Periodontitis Patients (NA)
• Evaluation of Efficacy of Aloevera in the Treatment of Oral Submucous Fibrosis- A Clinical Study (PHASE3)
• Clinical Study to Evaluate Safety and Efficacy of KAM1403 Gel to Treat Radiation Dermatitis (PHASE2)

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

• aloevera gel CI brief — competitive landscape report
• aloevera gel updates RSS · CI watch RSS
• The Oxford Dental College, Hospital and Research Center, Bangalore, India portfolio CI

Frequently asked questions about aloevera gel

Related

• Drug class: All Herbal/botanical topical agent drugs
• Manufacturer: The Oxford Dental College, Hospital and Research Center, Bangalore, India — full pipeline
• Therapeutic area: All drugs in Dermatology
• Indication: Drugs for Wound healing and tissue repair
• Indication: Drugs for Minor burns and scalds
• Indication: Drugs for Oral mucositis and dental wound care
• Also known as: AV

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing