{"id":"aloevera-gel","safety":{"commonSideEffects":[{"rate":null,"effect":"Contact dermatitis or local irritation"},{"rate":null,"effect":"Allergic reaction"}]},"_chembl":{"chemblId":"CHEMBL2109015","moleculeType":"Unknown"},"_dailymed":{"setId":"84b9f4ae-b82e-089a-e053-2a91aa0ad230","title":"ALOEVERA SOOTHING GEL 98% (ALOE, GLYCERIN) LIQUID [LYDIA CO., LTD.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Aloe vera contains multiple active constituents including acemannan (a polysaccharide), aloin, and various amino acids that stimulate fibroblast activity, enhance collagen synthesis, and promote epithelialization. The gel also exhibits antimicrobial and anti-inflammatory properties that reduce bacterial colonization and inflammatory cytokine production at wound sites, facilitating faster healing and tissue regeneration.","oneSentence":"Aloe vera gel provides topical wound healing and anti-inflammatory effects through polysaccharides, anthraquinones, and other bioactive compounds that promote tissue repair and reduce inflammation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:00:52.441Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Wound healing and tissue repair"},{"name":"Minor burns and scalds"},{"name":"Oral mucositis and dental wound care"}]},"trialDetails":[{"nctId":"NCT06862817","phase":"PHASE1, PHASE2","title":"Comparison Between the Effect of Aloe Vera and Benzydamine Hydrochloride Mouth Gel on Prevention of Pain and Progression of Radiation-induced Oral Mucositis","status":"COMPLETED","sponsor":"Minia University","startDate":"2023-11-01","conditions":"Radiation Indused Oral Mucositis","enrollment":30},{"nctId":"NCT05578638","phase":"NA","title":"Comparing Aloe Vera Gel and Rosemary Oil in Pressure Injury Prevention","status":"RECRUITING","sponsor":"Mansoura University","startDate":"2022-11-01","conditions":"Pressure Injury","enrollment":128},{"nctId":"NCT03941665","phase":"NA","title":"Use of Gelronate Gel vs. Aloevera in Preventing/Minimizing Radiation-induced Dermatitis in Breast Cancer Patients","status":"COMPLETED","sponsor":"Sheba Medical Center","startDate":"2019-03-25","conditions":"Radiation Dermatitis","enrollment":136},{"nctId":"NCT03204097","phase":"PHASE2, PHASE3","title":"Local Host Modulating Agents Alendronate & Aloe Vera for Treatment of Furcation Defects in Chronic Periodontitis","status":"COMPLETED","sponsor":"Government Dental College and Research Institute, Bangalore","startDate":"2016-03","conditions":"Chronic Periodontitis","enrollment":90},{"nctId":"NCT03204071","phase":"PHASE2, PHASE3","title":"Locally Delivered Metformin and Aloe Vera for Treatment of Intrabody Defects in Chronic Periodontitis","status":"COMPLETED","sponsor":"Government Dental College and Research Institute, Bangalore","startDate":"2016-02","conditions":"Chronic Periodontitis","enrollment":90},{"nctId":"NCT03083535","phase":"NA","title":"Efficacy of AloeVera Gel Gum Massaging and Adjunct to Scaling and Root Planing in Chronic Periodontitis Patients","status":"UNKNOWN","sponsor":"Government College of Dentistry, Indore","startDate":"2016-01","conditions":"CHRONIC PERIODONTITIS","enrollment":120},{"nctId":"NCT02714543","phase":"PHASE3","title":"Evaluation of Efficacy of Aloevera in the Treatment of Oral Submucous Fibrosis- A Clinical Study","status":"COMPLETED","sponsor":"The Oxford Dental College, Hospital and Research Center, Bangalore, India","startDate":"2013-11","conditions":"Oral SubMucous Fibrosis","enrollment":74},{"nctId":"NCT02051907","phase":"PHASE2","title":"Clinical Study to Evaluate Safety and Efficacy of KAM1403 Gel to Treat Radiation Dermatitis","status":"UNKNOWN","sponsor":"Kamedis Ltd.","startDate":"2014-03","conditions":"Radiation Dermatitis","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["AV"],"phase":"marketed","status":"active","brandName":"aloevera gel","genericName":"aloevera gel","companyName":"The Oxford Dental College, Hospital and Research Center, Bangalore, India","companyId":"the-oxford-dental-college-hospital-and-research-center-bangalore-india","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Aloe vera gel has been studied as a potential treatment for several conditions, including radiation dermatitis, radiation-induced oral mucositis, oral submucous fibrosis, and chronic periodontitis. The exact mechanism of aloe vera gel is unknown, but it has been compared to Gelronate gel in clinical trials for preventing or minimizing radiation-induced dermatitis in breast cancer patients.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}