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Alcohol free essential oils
Alcohol-free essential oils deliver concentrated plant-derived volatile compounds that exert antimicrobial, anti-inflammatory, and potentially analgesic effects through direct chemical interaction with microbial membranes and host tissue receptors.
Alcohol-free essential oils deliver concentrated plant-derived volatile compounds that exert antimicrobial, anti-inflammatory, and potentially analgesic effects through direct chemical interaction with microbial membranes and host tissue receptors. Used for Topical antimicrobial and anti-inflammatory applications (marketed formulation).
At a glance
| Generic name | Alcohol free essential oils |
|---|---|
| Also known as | Listerine Zero |
| Sponsor | University of Santiago de Compostela |
| Modality | Small molecule |
| Therapeutic area | Dermatology, Microbiology, Wellness |
| Phase | FDA-approved |
Mechanism of action
Essential oils are complex mixtures of terpenes, phenols, and other volatile organic compounds extracted from plants. When formulated without alcohol, they retain their bioactive constituents while improving tolerability and reducing irritation. These compounds can penetrate microbial cell walls, disrupt membrane integrity, and modulate inflammatory pathways in host tissues.
Approved indications
- Topical antimicrobial and anti-inflammatory applications (marketed formulation)
Common side effects
- Skin irritation or sensitization
- Allergic contact dermatitis
Key clinical trials
- Antiplaque Efficacy and Patient Reported Outcome of Chlorohexidine, Cetylpyridinium Chloride, and Essential Oil Mouthwashes in Orthodontic Patients (NA)
- Comparative Efficacy of Floss and Essential Oil/CPC+Zn Mouthwashes in Reducing Dental Plaque and Gingivitis (PHASE4)
- Comparative Study to Evaluate the Efficacy of an Alcohol-free Mouthwash Regimen With CPC+Zn, Flossing and Brushing, and an Alcohol-based Mouthwash Regimen With Essential Oils in Reducing Plaque and Gingivitis. (PHASE3)
- Comparative Study of CPC+Zn Mouthwash, Dental Floss, and Essential Oils Mouthwash on Plaque and Gingivitis Reduction (PHASE3)
- A Study of Mouth Rinses in Type 1 and Type 2 Diabetic Participants (PHASE4)
- Effect of Single Rinsing With Three Different Types of Mouthwash on VSC Levels in Morning Breath (NA)
- Dental Implants and Mouth Rinse (PHASE2)
- Mouthwashes During Orthodontic Treatment (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Alcohol free essential oils CI brief — competitive landscape report
- Alcohol free essential oils updates RSS · CI watch RSS
- University of Santiago de Compostela portfolio CI