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NCT06598072: PGMWII
Comparative Study to Evaluate the Efficacy of an Alcohol-free Mouthwash Regimen With CPC+Zn, Flossing and Brushing, and an Alcohol-based Mouthwash Regimen With Essential Oils in Reducing Plaque and Gingivitis.
Phase 3 trial testing Mouthwash CPC+Zn+F in Gingival Bleeding in 120 participants. Completed in 16 December 2024.
16 December 2024
Quick facts
| Lead sponsor | Colgate Palmolive |
|---|---|
| Phase | Phase 3 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 120 |
| Start date | 17 September 2024 |
| Primary completion | 16 December 2024 |
| Estimated completion | 16 December 2024 |
| Sites | 1 location across Mexico |
Drugs / interventions tested
- Mouthwash CPC+Zn+F — full drug profile →
- Essential oils mouthwash
- Dental floss
Conditions studied
- Gingival Bleeding — all drugs for Gingival Bleeding →
- Plaque Induced Gingival Disease — all drugs for Plaque Induced Gingival Disease →
- Gingival Diseases — all drugs for Gingival Diseases →
- Gingivitis and Periodontal Diseases — all drugs for Gingivitis and Periodontal Diseases →
Sponsor
Colgate Palmolive — full company profile →
Who can join
Adults 18 to 65, any sex, with Gingival Bleeding or Plaque Induced Gingival Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This is a Phase III, randomized, one-center, parallel group, double blinded, clinical study to evaluate the efficacy of an alcohol-free mouthwash containing CPC+Zn as compared to dental flossing and to rising with an essential oils containing alcohol mouthwash in reducing dental plaque and gingivitis. One hundred and twenty participants, aged between 18 and 65 years, will be included and followed for 12 weeks.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT06598072
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Mouthwash CPC+Zn+F
Trials testing the same drug.
- NCT06607263 — Comparative Study of CPC+Zn Mouthwash, Dental Floss, and Essential Oils Mouthwash on Plaque and Gingivitis Reduction · Phase 3 · completed
Other recruiting trials for Gingival Bleeding
Currently open trials in the same condition.
- NCT07501455 — Comparison of the Effects of Oral Hygiene Regimens on Clinical, Immunomodulatory, and Microbial Outcomes and Oral Tolera · NA · recruiting
- NCT07255976 — Comparison of Effectiveness of Gingival Displacement Using Retraction Cord and Aluminum Chloride Gel · Phase 4 · recruiting
- NCT06752291 — EFFECTIVENESS of WATER FLOSS in PLAQUE REMOVAL and PREVENTION of WHITE SPOT LESIONS in ORTHODONTIC PATIENTS: a RANDOMISE · NA · active not recruiting
- NCT06490679 — Evaluation Of Nonsurgical Treatment Of Deep Periodontal Pockets (7-10mm) Using AIRFLOW® Prophylaxis Master Device With E · NA · recruiting
- NCT06351982 — Treatment Of Shallow Periodontal Pockets 4-6mm Using AIRFLOW Prophylaxis Master Device With Erythritol vs Manual Scalers · NA · recruiting
Other Colgate Palmolive trials
Trials by the same sponsor.
- NCT07398846 — Efficacy of a Stannous Fluoride Toothpaste, Cetylpyridinium Chloride Mouthwash, and Battery Toothbrush Regimen in Reduci · Phase 3 · recruiting
- NCT07276672 — Efficacy of a Toothpaste Containing Hydrogen Peroxide as Compared to a Regular Fluoride Toothpaste Without Hydrogen Pero · Phase 3 · completed
- NCT07225478 — Clinical Study to Evaluate the Tooth Whitening Efficacy of a New NextGen In-office Whitening System · Phase 3 · completed
- NCT07224828 — The Efficacy of a Battery Toothbrush in the Reduction of Established Plaque and Gingivitis · Phase 3 · completed
- NCT07134231 — Clinical Study to Evaluate the Anti-cavity Efficacy of Three Dentifrices: An In Situ Model · Phase 3 · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06598072 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Colgate Palmolive
- Last refreshed: 14 April 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06598072.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing