Last reviewed · How we verify
Alclometasone dipropionate cream
Alclometasone dipropionate is a topical corticosteroid that suppresses inflammatory and immune responses in the skin by binding to glucocorticoid receptors.
Alclometasone dipropionate is a topical corticosteroid that suppresses inflammatory and immune responses in the skin by binding to glucocorticoid receptors. Used for Inflammatory and pruritic dermatoses responsive to topical corticosteroids (e.g., eczema, dermatitis, psoriasis).
At a glance
| Generic name | Alclometasone dipropionate cream |
|---|---|
| Sponsor | GlaxoSmithKline |
| Drug class | Topical corticosteroid (medium potency) |
| Target | Glucocorticoid receptor |
| Modality | Small molecule |
| Therapeutic area | Dermatology |
| Phase | Phase 2 |
Mechanism of action
As a medium-potency corticosteroid, alclometasone dipropionate reduces inflammation, itching, and skin lesions by activating intracellular glucocorticoid receptors, which then modulate the expression of pro-inflammatory cytokines and immune cell activity. The dipropionate ester formulation enhances skin penetration and potency compared to the parent compound. It is applied topically to affected skin areas where it exerts local anti-inflammatory effects with minimal systemic absorption.
Approved indications
- Inflammatory and pruritic dermatoses responsive to topical corticosteroids (e.g., eczema, dermatitis, psoriasis)
Common side effects
- Skin atrophy
- Striae
- Telangiectasia
- Local irritation or burning
- Folliculitis
Key clinical trials
- Study Of Dacomitinib (PF-00299804) In Advanced NSCLC Patients (Post Chemo Or Select First Line) To Evaluate Prophylactic Intervention On Derm And GI AEs And PRO (PHASE2)
- Study to Evaluate Product Duration of Use Experience With Alclometasone Dipropionate Cream (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Alclometasone dipropionate cream CI brief — competitive landscape report
- Alclometasone dipropionate cream updates RSS · CI watch RSS
- GlaxoSmithKline portfolio CI