{"id":"alclometasone-dipropionate-cream","safety":{"commonSideEffects":[{"rate":null,"effect":"Skin atrophy"},{"rate":null,"effect":"Striae"},{"rate":null,"effect":"Telangiectasia"},{"rate":null,"effect":"Local irritation or burning"},{"rate":null,"effect":"Folliculitis"}]},"_chembl":{"chemblId":"CHEMBL1200989","moleculeType":"Small molecule","molecularWeight":"521.05"},"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"As a medium-potency corticosteroid, alclometasone dipropionate reduces inflammation, itching, and skin lesions by activating intracellular glucocorticoid receptors, which then modulate the expression of pro-inflammatory cytokines and immune cell activity. The dipropionate ester formulation enhances skin penetration and potency compared to the parent compound. It is applied topically to affected skin areas where it exerts local anti-inflammatory effects with minimal systemic absorption.","oneSentence":"Alclometasone dipropionate is a topical corticosteroid that suppresses inflammatory and immune responses in the skin by binding to glucocorticoid receptors.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T03:20:48.742Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Inflammatory and pruritic dermatoses responsive to topical corticosteroids (e.g., eczema, dermatitis, psoriasis)"}]},"trialDetails":[{"nctId":"NCT01465802","phase":"PHASE2","title":"Study Of Dacomitinib (PF-00299804) In Advanced NSCLC Patients (Post Chemo Or Select First Line) To Evaluate Prophylactic Intervention On Derm And GI AEs And PRO","status":"COMPLETED","sponsor":"Pfizer","startDate":"2011-12-26","conditions":"Non Small Cell Lung Cancer (NSCLC)","enrollment":236},{"nctId":"NCT02075632","phase":"PHASE2","title":"Study to Evaluate Product Duration of Use Experience With Alclometasone Dipropionate Cream","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2006-09","conditions":"Eczema, Allergy Symptoms, Psoriasis","enrollment":310}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":6,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_2","status":"active","brandName":"Alclometasone dipropionate cream","genericName":"Alclometasone dipropionate cream","companyName":"GlaxoSmithKline","companyId":"gsk","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Alclometasone dipropionate is a topical corticosteroid that suppresses inflammatory and immune responses in the skin by binding to glucocorticoid receptors. Used for Inflammatory and pruritic dermatoses responsive to topical corticosteroids (e.g., eczema, dermatitis, psoriasis).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}