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Albumin Taxol
Albumin Taxol is a Taxane; microtubule stabilizer Small molecule drug developed by Fujian Medical University. It is currently in Phase 3 development for Metastatic breast cancer, Non-small cell lung cancer, Pancreatic cancer.
Albumin-bound paclitaxel (nab-paclitaxel) stabilizes microtubules by binding to β-tubulin, preventing their depolymerization and halting cell division.
Albumin-bound paclitaxel (nab-paclitaxel) stabilizes microtubules by binding to β-tubulin, preventing their depolymerization and halting cell division. Used for Metastatic breast cancer, Non-small cell lung cancer, Pancreatic cancer.
At a glance
| Generic name | Albumin Taxol |
|---|---|
| Sponsor | Fujian Medical University |
| Drug class | Taxane; microtubule stabilizer |
| Target | β-tubulin |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | Phase 3 |
Mechanism of action
Paclitaxel is a taxane chemotherapy agent that binds to β-tubulin dimers within microtubules, preventing their disassembly and causing mitotic arrest. The albumin nanoparticle formulation improves drug delivery and reduces toxicity compared to conventional paclitaxel by enabling albumin-receptor-mediated endocytosis into tumor cells and reducing Cremophor EL-related hypersensitivity reactions.
Approved indications
- Metastatic breast cancer
- Non-small cell lung cancer
- Pancreatic cancer
Common side effects
- Neutropenia
- Peripheral neuropathy
- Anemia
- Thrombocytopenia
- Fatigue
- Myalgia/arthralgia
- Nausea/vomiting
Key clinical trials
- Durvalumab in Combination With Chemotherapy in Treating Patients With Advanced Solid Tumors, DURVA+ Trial (PHASE2)
- A Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Triple-Negative Breast Cancer (MK-2870-011/TroFuse-011) (PHASE3)
- Clinical Study on the Efficacy and Safety of Iparomlimab and Tuvonralimab Injection Combined With Nab-Paclitaxel in Neoadjuvant Therapy for Locally Advanced Resectable Esophageal Squamous Cell Carcinoma (PHASE2)
- Testing the Addition of an Individualized Vaccine to Durvalumab and Tremelimumab and Chemotherapy in Patients With Metastatic Triple Negative Breast Cancer (PHASE2)
- Studying Chemotherapy With or Without Panitumumab for Unresectable, Locally Advanced, or Metastatic Pancreatic Cancer Without KRAS Mutations (PHASE3)
- Pembrolizumab With or Without Maintenance Sacituzumab Tirumotecan (Sac-TMT; MK-2870) in Metastatic Squamous Non-small Cell Lung Cancer (NSCLC) [MK-2870-023] (PHASE3)
- A Study to Evaluate the Bioavailability of Pembrolizumab (MK-3475) Via Subcutaneous (SC) Injection of Pembrolizumab Formulated With Berahyaluronidase Alfa (MK-5180) [MK-3475A] In Advanced Solid Tumors (MK-3475A-C18) (PHASE1)
- Relacorilant With Nab-Paclitaxel and Gemcitabine in Patients With Metastatic Pancreatic Adenocarcinoma (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Albumin Taxol CI brief — competitive landscape report
- Albumin Taxol updates RSS · CI watch RSS
- Fujian Medical University portfolio CI
Frequently asked questions about Albumin Taxol
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Related
- Drug class: All Taxane; microtubule stabilizer drugs
- Target: All drugs targeting β-tubulin
- Manufacturer: Fujian Medical University — full pipeline
- Therapeutic area: All drugs in Oncology
- Indication: Drugs for Metastatic breast cancer
- Indication: Drugs for Non-small cell lung cancer
- Indication: Drugs for Pancreatic cancer
- Compare: Albumin Taxol vs similar drugs
- Pricing: Albumin Taxol cost, discount & access