Last reviewed · How we verify
AL unit dose age specific pre-packs
AL (artemether-lumefantrine) is a fixed-dose combination antimalarial that kills malaria parasites by disrupting their hemoglobin metabolism and DNA replication.
AL (artemether-lumefantrine) is a fixed-dose combination antimalarial that kills malaria parasites by disrupting their hemoglobin metabolism and DNA replication. Used for Uncomplicated Plasmodium falciparum malaria in children (age-specific formulation).
At a glance
| Generic name | AL unit dose age specific pre-packs |
|---|---|
| Also known as | Coartem pre-packs |
| Sponsor | Malaria Consortium, Uganda |
| Drug class | Artemisinin-based combination therapy (ACT) |
| Target | Parasite hemoglobin metabolism; mitochondrial electron transport |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease / Parasitology |
| Phase | Phase 3 |
Mechanism of action
Artemether, a semi-synthetic artemisinin derivative, generates reactive oxygen species that damage parasite proteins and DNA. Lumefantrine, a biguanide, inhibits parasite mitochondrial function and heme polymerization. Together in age-specific pre-packs, they provide rapid parasite clearance and extended post-treatment prophylaxis, with dosing tailored to pediatric weight bands.
Approved indications
- Uncomplicated Plasmodium falciparum malaria in children (age-specific formulation)
Common side effects
- Headache
- Fever
- Nausea
- Vomiting
- Abdominal pain
- Diarrhea
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- AL unit dose age specific pre-packs CI brief — competitive landscape report
- AL unit dose age specific pre-packs updates RSS · CI watch RSS
- Malaria Consortium, Uganda portfolio CI