{"id":"al-unit-dose-age-specific-pre-packs","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Vomiting"},{"rate":null,"effect":"Abdominal pain"},{"rate":null,"effect":"Diarrhea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Artemether, a semi-synthetic artemisinin derivative, generates reactive oxygen species that damage parasite proteins and DNA. Lumefantrine, a biguanide, inhibits parasite mitochondrial function and heme polymerization. Together in age-specific pre-packs, they provide rapid parasite clearance and extended post-treatment prophylaxis, with dosing tailored to pediatric weight bands.","oneSentence":"AL (artemether-lumefantrine) is a fixed-dose combination antimalarial that kills malaria parasites by disrupting their hemoglobin metabolism and DNA replication.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:00:27.050Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Uncomplicated Plasmodium falciparum malaria in children (age-specific formulation)"}]},"trialDetails":[{"nctId":"NCT01065116","phase":"PHASE3","title":"Artemether-Lumefantrine (AL) Unit Dose Pre-packs Versus Blister Packs","status":"COMPLETED","sponsor":"Malaria Consortium, Uganda","startDate":"2010-03","conditions":"Malaria","enrollment":920}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Coartem pre-packs"],"phase":"phase_3","status":"active","brandName":"AL unit dose age specific pre-packs","genericName":"AL unit dose age specific pre-packs","companyName":"Malaria Consortium, Uganda","companyId":"malaria-consortium-uganda","modality":"Small molecule","firstApprovalDate":"","aiSummary":"AL (artemether-lumefantrine) is a fixed-dose combination antimalarial that kills malaria parasites by disrupting their hemoglobin metabolism and DNA replication. Used for Uncomplicated Plasmodium falciparum malaria in children (age-specific formulation).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}