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Administration of Ropivacaïne
Ropivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.
Ropivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. Used for Local infiltration anesthesia for surgical procedures, Peripheral nerve blocks, Epidural anesthesia.
At a glance
| Generic name | Administration of Ropivacaïne |
|---|---|
| Sponsor | Centre Hospitalier Departemental Vendee |
| Drug class | Local anesthetic (amide) |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia / Pain Management |
| Phase | Phase 3 |
Mechanism of action
Ropivacaine is an amide-type local anesthetic that reversibly inhibits sodium influx into nerve fibers, thereby stabilizing the neuronal membrane and preventing depolarization. This action blocks pain signal transmission along peripheral nerves. It is commonly used for infiltration anesthesia, nerve blocks, and epidural/spinal anesthesia in surgical and pain management procedures.
Approved indications
- Local infiltration anesthesia for surgical procedures
- Peripheral nerve blocks
- Epidural anesthesia
- Spinal anesthesia
Common side effects
- Injection site reactions (pain, erythema)
- Transient neurological symptoms
- Hypotension
- Bradycardia
- Systemic toxicity (CNS and cardiac effects at high doses)
Key clinical trials
- Effects of Insufflated Gas on Core Temperature and Post-operative Pain During Laparoscopic Surgery (NA)
- Comparative Study of the Effects of Two Local Anesthetics Administered Intrathecally: 0.5% Levobupivacaine and Ropivacaine 0.5% (PHASE4)
- Study of the Analgesic Effect of the Perineal Infiltration of Ropivacaine 0.75% Versus Placebo in Post-episiotomy Perineal Pain (PHASE3)
- Analgesic Efficacy of Continuous Infusion of Local Anaesthetic Versus Single-shot Injection Interscalene Block (NA)
- Comparison of Administation Routes of Ropivacaine (PHASE4)
- Perioperative Analgesia by Femoral Perineural Catheter for Femoral Neck Fracture - Study KTcol (PHASE4)
- Multicenter Randomized Double-blind Study Evaluating the Effects of Botulinum Toxin A Associated With ropivacaïne Versus ropivacaïne Alone in the Treatment of the Myofascial Pelviperineal Pain (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Administration of Ropivacaïne CI brief — competitive landscape report
- Administration of Ropivacaïne updates RSS · CI watch RSS
- Centre Hospitalier Departemental Vendee portfolio CI