{"id":"administration-of-ropivaca-ne","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site reactions (pain, erythema)"},{"rate":null,"effect":"Transient neurological symptoms"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Systemic toxicity (CNS and cardiac effects at high doses)"}]},"_chembl":{"chemblId":"CHEMBL3770173","moleculeType":"Small molecule","molecularWeight":"440.32"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ropivacaine is an amide-type local anesthetic that reversibly inhibits sodium influx into nerve fibers, thereby stabilizing the neuronal membrane and preventing depolarization. This action blocks pain signal transmission along peripheral nerves. It is commonly used for infiltration anesthesia, nerve blocks, and epidural/spinal anesthesia in surgical and pain management procedures.","oneSentence":"Ropivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:59:55.868Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Local infiltration anesthesia for surgical procedures"},{"name":"Peripheral nerve blocks"},{"name":"Epidural anesthesia"},{"name":"Spinal anesthesia"}]},"trialDetails":[{"nctId":"NCT00372268","phase":"NA","title":"Effects of Insufflated Gas on Core Temperature and Post-operative Pain During Laparoscopic Surgery","status":"COMPLETED","sponsor":"University Hospital, Strasbourg, France","startDate":"2006-01","conditions":"Laparoscopy, Pain, Postoperative, Hypothermia","enrollment":248},{"nctId":"NCT01935596","phase":"PHASE4","title":"Comparative Study of the Effects of Two Local Anesthetics Administered Intrathecally: 0.5% Levobupivacaine and Ropivacaine 0.5%","status":"COMPLETED","sponsor":"Centre Hospitalier Universitaire, Amiens","startDate":"2013-05","conditions":"Patients Undergoing Lower Limb Surgery","enrollment":50},{"nctId":"NCT03084549","phase":"PHASE3","title":"Study of the Analgesic Effect of the Perineal Infiltration of Ropivacaine 0.75% Versus Placebo in Post-episiotomy Perineal Pain","status":"COMPLETED","sponsor":"Centre Hospitalier Departemental Vendee","startDate":"2017-10-24","conditions":"Episiotomy","enrollment":272},{"nctId":"NCT04394130","phase":"NA","title":"Analgesic Efficacy of Continuous Infusion of Local Anaesthetic Versus Single-shot Injection Interscalene Block","status":"COMPLETED","sponsor":"Eric Albrecht","startDate":"2020-05-12","conditions":"Analgesia","enrollment":60},{"nctId":"NCT04459026","phase":"PHASE4","title":"Comparison of Administation Routes of Ropivacaine","status":"COMPLETED","sponsor":"Universiteit Antwerpen","startDate":"2017-07-01","conditions":"Postoperative Pain","enrollment":60},{"nctId":"NCT01052974","phase":"PHASE4","title":"Perioperative Analgesia by Femoral Perineural Catheter for Femoral Neck Fracture - Study KTcol","status":"COMPLETED","sponsor":"University Hospital, Angers","startDate":"2009-03-26","conditions":"Femoral Neck Fracture","enrollment":60},{"nctId":"NCT01967524","phase":"PHASE3","title":"Multicenter Randomized Double-blind Study Evaluating the Effects of Botulinum Toxin A Associated With ropivacaïne Versus ropivacaïne Alone in the Treatment of the Myofascial Pelviperineal Pain","status":"COMPLETED","sponsor":"Nantes University Hospital","startDate":"2013-09","conditions":"Myofascial Pelviperineal Pain","enrollment":80}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Administration of Ropivacaïne","genericName":"Administration of Ropivacaïne","companyName":"Centre Hospitalier Departemental Vendee","companyId":"centre-hospitalier-departemental-vendee","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ropivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. Used for Local infiltration anesthesia for surgical procedures, Peripheral nerve blocks, Epidural anesthesia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}