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Adductor Canal Block with Morphine
Morphine delivered via adductor canal block provides regional anesthesia and analgesia by blocking nerve conduction in the femoral nerve and its branches while achieving high local drug concentrations.
Morphine delivered via adductor canal block provides regional anesthesia and analgesia by blocking nerve conduction in the femoral nerve and its branches while achieving high local drug concentrations. Used for Postoperative analgesia following knee surgery, Postoperative analgesia following lower extremity surgery.
At a glance
| Generic name | Adductor Canal Block with Morphine |
|---|---|
| Also known as | ropivacaine with epinephrine and spinal intrathecal morphine |
| Sponsor | University Health Network, Toronto |
| Drug class | Regional anesthetic with opioid adjuvant |
| Target | Peripheral opioid receptors (mu-opioid receptor) |
| Modality | Small molecule |
| Therapeutic area | Anesthesia and Pain Management |
| Phase | FDA-approved |
Mechanism of action
The adductor canal block is a regional anesthesia technique that targets the saphenous nerve and other branches of the femoral nerve in the adductor canal region of the thigh. When morphine is added to the local anesthetic solution, it enhances and prolongs analgesia through opioid receptor activation at peripheral nerve terminals and spinal cord levels, reducing postoperative pain without the systemic side effects of intravenous opioids.
Approved indications
- Postoperative analgesia following knee surgery
- Postoperative analgesia following lower extremity surgery
Common side effects
- Nerve injury or neuropraxia
- Vascular puncture
- Local anesthetic toxicity
- Hematoma
- Infection at injection site
Key clinical trials
- COMPARISON OF THE EFFECT OF DISTAL ADDUCTOR CANAL BLOCK COMBINED WITH GENICULAR NERVE BLOCK OR PERIARTICULAR INJECTION ON POSTOPERATIVE QOR-15 IN TOTAL KNEE ARTHROPLASTIES (NA)
- Impact of Opioid Avoidance Protocol for ACL Reconstruction
- Does PAI Reduce Pain After TKA Among Knee Arthroplasty Patients Receiving ACB & IPACK? (PHASE4)
- Comparison of Two Multimodal Analgesia Regimens in Total Knee Arthroplasty (NA)
- Intraosseous Morphine Administration During Anterior Cruciate Ligament Reconstruction (PHASE4)
- Modified TIPS Block for Total Knee Arthroplasty (PHASE4)
- Comparing Two Regional Anesthesia Interventions for Knee Arthroplasty. (NA)
- The Quality of Recovery After Intrathecal Morphine or Adductor Canal Block in Anterior Cruciate Ligament Reconstruction (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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