{"id":"adductor-canal-block-with-morphine","safety":{"commonSideEffects":[{"rate":null,"effect":"Nerve injury or neuropraxia"},{"rate":null,"effect":"Vascular puncture"},{"rate":null,"effect":"Local anesthetic toxicity"},{"rate":null,"effect":"Hematoma"},{"rate":null,"effect":"Infection at injection site"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The adductor canal block is a regional anesthesia technique that targets the saphenous nerve and other branches of the femoral nerve in the adductor canal region of the thigh. When morphine is added to the local anesthetic solution, it enhances and prolongs analgesia through opioid receptor activation at peripheral nerve terminals and spinal cord levels, reducing postoperative pain without the systemic side effects of intravenous opioids.","oneSentence":"Morphine delivered via adductor canal block provides regional anesthesia and analgesia by blocking nerve conduction in the femoral nerve and its branches while achieving high local drug concentrations.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:18:08.924Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Postoperative analgesia following knee surgery"},{"name":"Postoperative analgesia following lower extremity surgery"}]},"trialDetails":[{"nctId":"NCT07077720","phase":"NA","title":"COMPARISON OF THE EFFECT OF DISTAL ADDUCTOR CANAL BLOCK COMBINED WITH GENICULAR NERVE BLOCK OR PERIARTICULAR INJECTION ON POSTOPERATIVE QOR-15 IN TOTAL KNEE ARTHROPLASTIES","status":"COMPLETED","sponsor":"Bezmialem Vakif University","startDate":"2025-01-30","conditions":"Postoperative Pain, Recovery","enrollment":60},{"nctId":"NCT06340932","phase":"","title":"Impact of Opioid Avoidance Protocol for ACL Reconstruction","status":"COMPLETED","sponsor":"Matthew Varacallo","startDate":"2024-04-27","conditions":"ACL Tear, Post Operative Pain","enrollment":32},{"nctId":"NCT04749615","phase":"PHASE4","title":"Does PAI Reduce Pain After TKA Among Knee Arthroplasty Patients Receiving ACB & IPACK?","status":"COMPLETED","sponsor":"Hospital for Special Surgery, New York","startDate":"2020-12-17","conditions":"Total Knee Athroplasty","enrollment":94},{"nctId":"NCT03990038","phase":"NA","title":"Comparison of Two Multimodal Analgesia Regimens in Total Knee Arthroplasty","status":"TERMINATED","sponsor":"Ciusss de L'Est de l'Île de Montréal","startDate":"2019-08-01","conditions":"Postoperative Pain","enrollment":2},{"nctId":"NCT06511232","phase":"PHASE4","title":"Intraosseous Morphine Administration During Anterior Cruciate Ligament Reconstruction","status":"RECRUITING","sponsor":"The Methodist Hospital Research Institute","startDate":"2024-08-19","conditions":"Anterior Cruciate Ligament Tear, Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture","enrollment":84},{"nctId":"NCT06539910","phase":"PHASE4","title":"Modified TIPS Block for Total Knee Arthroplasty","status":"NOT_YET_RECRUITING","sponsor":"Alexandria University","startDate":"2024-08","conditions":"Knee Arthropathy, Anesthesia, Local","enrollment":90},{"nctId":"NCT03944005","phase":"NA","title":"Comparing Two Regional Anesthesia Interventions for Knee Arthroplasty.","status":"WITHDRAWN","sponsor":"Western University, Canada","startDate":"2020-07","conditions":"Knee Arthroplasty","enrollment":""},{"nctId":"NCT05742958","phase":"PHASE4","title":"The Quality of Recovery After Intrathecal Morphine or Adductor Canal Block in Anterior Cruciate Ligament Reconstruction","status":"UNKNOWN","sponsor":"Cukurova University","startDate":"2023-06-07","conditions":"Adductor Canal Block, Intrathecal Morphine, Arthroscopic Anterior Cruciate Ligament Reconstruction","enrollment":70},{"nctId":"NCT05669898","phase":"NA","title":"Continuous Adductor Canal Infusion vs. Single-injection Adductor Canal Block for Total Knee Arthroplasty","status":"UNKNOWN","sponsor":"Taipei Veterans General Hospital, Taiwan","startDate":"2019-05-21","conditions":"Arthroplasty, Replacement, Knee, Pain, Postoperative, Multimodal Analgesia","enrollment":80},{"nctId":"NCT05439343","phase":"NA","title":"Adductor Canal Block and Multimodal Local Infiltration Analgesia in Patients Receiving Total Knee Arthroplasty","status":"UNKNOWN","sponsor":"Taipei Veterans General Hospital, Taiwan","startDate":"2018-10-15","conditions":"Arthroplasty, Replacement, Knee, Analgesia, Rehabilitation","enrollment":64},{"nctId":"NCT05161221","phase":"PHASE3","title":"Post Operative Pain Management Through Adductor Canal Block With Bupivacaine for ACL Reconstruction","status":"UNKNOWN","sponsor":"Rothman Institute Orthopaedics","startDate":"2021-12-06","conditions":"Pain, Postoperative, ACL","enrollment":154},{"nctId":"NCT04814303","phase":"NA","title":"Impact of Adductor Canal Block on Functional Recovery","status":"UNKNOWN","sponsor":"Assiut University","startDate":"2021-05","conditions":"Total Knee Replacement","enrollment":200},{"nctId":"NCT04797546","phase":"PHASE1","title":"Adductor Canal Block Versus Patient Controlled Analgesia, in the Surgical Stress Response for Anterior Cruciate Ligament Repair","status":"WITHDRAWN","sponsor":"Pontificia Universidad Catolica de Chile","startDate":"2016-09","conditions":"Anesthesia, Stress, Physiological, Surgery","enrollment":""},{"nctId":"NCT04314505","phase":"PHASE4","title":"Opioid-Sparing Protocol Comparing With Opioid-based Protocol After Bilateral Total Knee Arthroplasty","status":"UNKNOWN","sponsor":"Taipei Veterans General Hospital, Taiwan","startDate":"2020-03-20","conditions":"Knee Replacement, Postoperative Pain, Opioid Use","enrollment":56},{"nctId":"NCT02292082","phase":"PHASE4","title":"The Combination of Adductor Canal Block and Periarticular Injection. A Novel Technique for Patients Undergoing Total Knee Replacement (ACB PAI)","status":"COMPLETED","sponsor":"Hospital for Special Surgery, New York","startDate":"2014-11","conditions":"Osteoarthritis","enrollment":111},{"nctId":"NCT03770806","phase":"NA","title":"Factors Affecting the Speed of Recovery After ACL Reconstruction","status":"COMPLETED","sponsor":"University of Washington","startDate":"2017-03-24","conditions":"Anterior Cruciate Ligament Injury, ACL Injury, ACL - Anterior Cruciate Ligament Rupture","enrollment":48},{"nctId":"NCT02411149","phase":"PHASE4","title":"Adductor Canal Block and Recovery After Total Knee Replacement Surgery","status":"COMPLETED","sponsor":"University Health Network, Toronto","startDate":"2014-04","conditions":"Total Knee Arthroplasty","enrollment":200},{"nctId":"NCT02539628","phase":"PHASE4","title":"Adductor Canal Block With Continuous Infusion Versus Intermittent Boluses and Morphine Consumption","status":"COMPLETED","sponsor":"Pia Jaeger","startDate":"2015-03","conditions":"Postoperative Pain","enrollment":110},{"nctId":"NCT02104934","phase":"NA","title":"A Randomised Controlled Trial Comparing Single Shot Adductor Canal Block With Local Infiltration Analgesia for Postoperative Analgesia After Total Knee Arthroplasty","status":"COMPLETED","sponsor":"Changi General Hospital","startDate":"2014-03","conditions":"Analgesia in Total Knee Arthroplasty","enrollment":40},{"nctId":"NCT02784041","phase":"NA","title":"Single Adductor-canal-block Versus Peri-articular Infiltration on Outcome After Total Knee Arthroplasty","status":"UNKNOWN","sponsor":"Peking Union Medical College Hospital","startDate":"2016-09","conditions":"Osteoarthritis,Knee","enrollment":200},{"nctId":"NCT02540070","phase":"PHASE3","title":"Evaluation of Motor Sparing Knee Block to Infiltration Analgesia for Pain Following Knee Arthroplasty","status":"UNKNOWN","sponsor":"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's","startDate":"2014-08","conditions":"Osteoarthritis, Knee Arthroplasty, Pain Management","enrollment":135},{"nctId":"NCT02197273","phase":"NA","title":"Liposomal Bupivacaine Versus Standard Analgesia in Total Joint Arthroplasty (TJA)","status":"COMPLETED","sponsor":"OhioHealth","startDate":"2014-07","conditions":"Osteoarthritis, Knee, Osteoarthritis, Hip, Osteoarthritis, Shoulder","enrollment":211},{"nctId":"NCT02082067","phase":"PHASE4","title":"Total Knee Prosthesis With Continuous Block of Adductor Canal and Outcome","status":"WITHDRAWN","sponsor":"ASST Gaetano Pini-CTO","startDate":"2014-03","conditions":"Total Knee Arthroplasty","enrollment":""},{"nctId":"NCT01797588","phase":"PHASE4","title":"Pain After Total Knee Arthroplasty: A Trial Examining Combined Adductor-canal Nerve Block and Periarticular Infiltration Versus Adductor Canal Nerve Block Versus Periarticular Infiltration","status":"COMPLETED","sponsor":"North York General Hospital","startDate":"2013-03","conditions":"Total Knee Arthroplasty, Postoperative Pain","enrollment":156},{"nctId":"NCT01191593","phase":"PHASE4","title":"The Efficacy of Adductor-Canal-Blockade on Pain and Morphine Consumption After Revision Knee Arthroplasty","status":"COMPLETED","sponsor":"Rigshospitalet, Denmark","startDate":"2010-09","conditions":"Postoperative Pain, Knee Arthroplasty","enrollment":36},{"nctId":"NCT01261897","phase":"PHASE4","title":"The Efficacy of Adductor-Canal-Blockade on Pain and Morphine Consumption After Total Knee Arthroplasty","status":"COMPLETED","sponsor":"Rigshospitalet, Denmark","startDate":"2011-01","conditions":"Postoperative Pain, Knee Arthroplasty","enrollment":40},{"nctId":"NCT01104883","phase":"PHASE4","title":"The Efficacy of Adductor-Canal-Blockade on Morphine Consumption, Pain and Mobilisation After Total Knee Arthroplasty","status":"COMPLETED","sponsor":"Rigshospitalet, Denmark","startDate":"2010-08","conditions":"Total Knee Arthroplasty","enrollment":70}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["ropivacaine with epinephrine and spinal intrathecal morphine"],"phase":"marketed","status":"active","brandName":"Adductor Canal Block with Morphine","genericName":"Adductor Canal Block with Morphine","companyName":"University Health Network, Toronto","companyId":"university-health-network-toronto","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Morphine delivered via adductor canal block provides regional anesthesia and analgesia by blocking nerve conduction in the femoral nerve and its branches while achieving high local drug concentrations. Used for Postoperative analgesia following knee surgery, Postoperative analgesia following lower extremity surgery.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}