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Ad26.ZEBOV, MVA-BN-Filo vaccine
Ad26.ZEBOV, MVA-BN-Filo vaccine is a Viral vector vaccine Biologic drug developed by London School of Hygiene and Tropical Medicine. It is currently in Phase 3 development for Prevention of Ebola virus disease (Zaire ebolavirus).
A two-dose heterologous prime-boost vaccine regimen that uses recombinant adenovirus 26 (Ad26) and modified vaccinia Ankara (MVA) vectors expressing Ebola virus glycoprotein to elicit cellular and humoral immune responses against Ebola virus.
A two-dose heterologous prime-boost vaccine regimen that uses recombinant adenovirus 26 (Ad26) and modified vaccinia Ankara (MVA) vectors expressing Ebola virus glycoprotein to elicit cellular and humoral immune responses against Ebola virus. Used for Prevention of Ebola virus disease (Zaire ebolavirus).
At a glance
| Generic name | Ad26.ZEBOV, MVA-BN-Filo vaccine |
|---|---|
| Sponsor | London School of Hygiene and Tropical Medicine |
| Drug class | Viral vector vaccine |
| Target | Ebola virus glycoprotein (ZEBOV) |
| Modality | Biologic |
| Therapeutic area | Immunology / Infectious Disease |
| Phase | Phase 3 |
Mechanism of action
The Ad26.ZEBOV vaccine primes the immune system with an adenovirus-vectored Ebola glycoprotein, followed by an MVA-vectored boost to enhance and broaden the immune response. This heterologous prime-boost strategy leverages two different viral vectors to maximize T-cell and antibody responses against Ebola virus, providing durable protection against infection.
Approved indications
- Prevention of Ebola virus disease (Zaire ebolavirus)
Common side effects
- Injection site pain or erythema
- Fatigue
- Myalgia
- Headache
- Fever
Key clinical trials
- A Safety Trial to Test MVA-BN(R)-Filo and Ad26.ZEBOV Vaccines in Healthy Volunteers (PHASE1)
- A Study to Evaluate the Immunogenicity, Safety and Tolerability of Ad26.ZEBOV and MVA-BN-Filo in Healthy Adult Participants (PHASE3)
- A Study of 2-dose Vaccine Regimen Using 3 Consecutive Lots of Ad26.ZEBOV and MVA-BN-Filo in Adult Participants (PHASE3)
- A Study of 2-dose Vaccination Regimen of Ad26.ZEBOV and MVA-BN-Filo in Infants (PHASE2)
- A Study to Evaluate A Range of Dose Levels of Ad26.ZEBOV and MVA-BN-Filo in Healthy Adult Participants (PHASE3)
- Ad26.ZEBOV, MVA-BN-Filo Vaccination in Children and Adults Previously Vaccinated With Control in the EBOVAC-Salone Study (PHASE2)
- Safety, Tolerability and Immunogenicity Study of 2-dose Heterologous Regimens for Ebola Vaccines Ad26.ZEBOV/MVA-BN-Filo (PHASE2)
- A Study of a 2-dose Ebola Vaccine Regimen of Ad26.ZEBOV Followed by MVA-BN-Filo in Healthy Pregnant Women (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Ad26.ZEBOV, MVA-BN-Filo vaccine CI brief — competitive landscape report
- Ad26.ZEBOV, MVA-BN-Filo vaccine updates RSS · CI watch RSS
- London School of Hygiene and Tropical Medicine portfolio CI
Frequently asked questions about Ad26.ZEBOV, MVA-BN-Filo vaccine
What is Ad26.ZEBOV, MVA-BN-Filo vaccine?
How does Ad26.ZEBOV, MVA-BN-Filo vaccine work?
What is Ad26.ZEBOV, MVA-BN-Filo vaccine used for?
Who makes Ad26.ZEBOV, MVA-BN-Filo vaccine?
What drug class is Ad26.ZEBOV, MVA-BN-Filo vaccine in?
What development phase is Ad26.ZEBOV, MVA-BN-Filo vaccine in?
What are the side effects of Ad26.ZEBOV, MVA-BN-Filo vaccine?
What does Ad26.ZEBOV, MVA-BN-Filo vaccine target?
Related
- Drug class: All Viral vector vaccine drugs
- Target: All drugs targeting Ebola virus glycoprotein (ZEBOV)
- Manufacturer: London School of Hygiene and Tropical Medicine — full pipeline
- Therapeutic area: All drugs in Immunology / Infectious Disease
- Indication: Drugs for Prevention of Ebola virus disease (Zaire ebolavirus)
- Compare: Ad26.ZEBOV, MVA-BN-Filo vaccine vs similar drugs
- Pricing: Ad26.ZEBOV, MVA-BN-Filo vaccine cost, discount & access