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Active Theramine and Active Naproxen
This combination product delivers active B-vitamin complex (Theramine) alongside the nonsteroidal anti-inflammatory drug naproxen to provide pain relief with nutritional support.
This combination product delivers active B-vitamin complex (Theramine) alongside the nonsteroidal anti-inflammatory drug naproxen to provide pain relief with nutritional support. Used for Neuropathic pain conditions, Inflammatory pain with nutritional deficiency.
At a glance
| Generic name | Active Theramine and Active Naproxen |
|---|---|
| Sponsor | Targeted Medical Pharma |
| Drug class | NSAID + B-vitamin combination |
| Target | COX-1/COX-2 (naproxen component); B-vitamin cofactors (Theramine component) |
| Modality | Small molecule |
| Therapeutic area | Pain Management / Neurology |
| Phase | Phase 3 |
Mechanism of action
Theramine is a proprietary formulation of B vitamins (thiamine, pyridoxine, cyanocobalamin) designed to support nerve health and reduce neuropathic pain signaling. Naproxen is a COX inhibitor that reduces prostaglandin-mediated inflammation and pain. The combination targets both inflammatory and neuropathic pain pathways simultaneously.
Approved indications
- Neuropathic pain conditions
- Inflammatory pain with nutritional deficiency
Common side effects
- Gastrointestinal upset (nausea, dyspepsia)
- Headache
- Dizziness
- NSAID-related GI complications (ulceration, bleeding)
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Active Theramine and Active Naproxen CI brief — competitive landscape report
- Active Theramine and Active Naproxen updates RSS · CI watch RSS
- Targeted Medical Pharma portfolio CI