{"id":"active-theramine-and-active-naproxen","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset (nausea, dyspepsia)"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"NSAID-related GI complications (ulceration, bleeding)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Theramine is a proprietary formulation of B vitamins (thiamine, pyridoxine, cyanocobalamin) designed to support nerve health and reduce neuropathic pain signaling. Naproxen is a COX inhibitor that reduces prostaglandin-mediated inflammation and pain. The combination targets both inflammatory and neuropathic pain pathways simultaneously.","oneSentence":"This combination product delivers active B-vitamin complex (Theramine) alongside the nonsteroidal anti-inflammatory drug naproxen to provide pain relief with nutritional support.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:59:16.538Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Neuropathic pain conditions"},{"name":"Inflammatory pain with nutritional deficiency"}]},"trialDetails":[{"nctId":"NCT01468025","phase":"PHASE3","title":"Effectiveness of Theramine on Chronic Back Pain","status":"COMPLETED","sponsor":"Targeted Medical Pharma","startDate":"2009-02","conditions":"Low Back Pain","enrollment":127}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Active Theramine and Active Naproxen","genericName":"Active Theramine and Active Naproxen","companyName":"Targeted Medical Pharma","companyId":"targeted-medical-pharma","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination product delivers active B-vitamin complex (Theramine) alongside the nonsteroidal anti-inflammatory drug naproxen to provide pain relief with nutritional support. Used for Neuropathic pain conditions, Inflammatory pain with nutritional deficiency.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}