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Active bupropion-Placebo gum
Bupropion is a norepinephrine-dopamine reuptake inhibitor that increases levels of these neurotransmitters in the brain to reduce cravings and withdrawal symptoms during smoking cessation.
Bupropion is a norepinephrine-dopamine reuptake inhibitor that increases levels of these neurotransmitters in the brain to reduce cravings and withdrawal symptoms during smoking cessation. Used for Smoking cessation aid.
At a glance
| Generic name | Active bupropion-Placebo gum |
|---|---|
| Sponsor | University of Wisconsin, Madison |
| Drug class | Norepinephrine-dopamine reuptake inhibitor (NDRI) |
| Target | Norepinephrine transporter (NET) and dopamine transporter (DAT) |
| Modality | Small molecule |
| Therapeutic area | Psychiatry / Smoking Cessation |
| Phase | FDA-approved |
Mechanism of action
Bupropion blocks the reuptake of norepinephrine and dopamine at the neuronal synapse, increasing their availability in the central nervous system. This mechanism helps counteract the dopamine deficit that occurs when nicotine is withdrawn, reducing both cravings and negative mood symptoms associated with smoking cessation. The gum formulation allows for local delivery and sustained release in the oral cavity.
Approved indications
- Smoking cessation aid
Common side effects
- Dry mouth
- Insomnia
- Headache
- Nausea
- Dizziness
Key clinical trials
- Maintenance Treatment for Abstinent Smokers (PHASE3)
- Bupropion Alone or Combined With Nicotine Gum (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Active bupropion-Placebo gum CI brief — competitive landscape report
- Active bupropion-Placebo gum updates RSS · CI watch RSS
- University of Wisconsin, Madison portfolio CI