{"id":"active-bupropion-placebo-gum","safety":{"commonSideEffects":[{"rate":null,"effect":"Dry mouth"},{"rate":null,"effect":"Insomnia"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Dizziness"}]},"_chembl":{"chemblId":"CHEMBL1201735","moleculeType":"Small molecule","molecularWeight":"320.66"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Bupropion blocks the reuptake of norepinephrine and dopamine at the neuronal synapse, increasing their availability in the central nervous system. This mechanism helps counteract the dopamine deficit that occurs when nicotine is withdrawn, reducing both cravings and negative mood symptoms associated with smoking cessation. The gum formulation allows for local delivery and sustained release in the oral cavity.","oneSentence":"Bupropion is a norepinephrine-dopamine reuptake inhibitor that increases levels of these neurotransmitters in the brain to reduce cravings and withdrawal symptoms during smoking cessation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:17:31.266Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Smoking cessation aid"}]},"trialDetails":[{"nctId":"NCT00063323","phase":"PHASE3","title":"Maintenance Treatment for Abstinent Smokers","status":"COMPLETED","sponsor":"National Institute on Drug Abuse (NIDA)","startDate":"2000-08","conditions":"Tobacco Use Disorder","enrollment":589},{"nctId":"NCT01621022","phase":"PHASE4","title":"Bupropion Alone or Combined With Nicotine Gum","status":"COMPLETED","sponsor":"University of Wisconsin, Madison","startDate":"2001-01","conditions":"Tobacco Dependence","enrollment":608}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Active bupropion-Placebo gum","genericName":"Active bupropion-Placebo gum","companyName":"University of Wisconsin, Madison","companyId":"university-of-wisconsin-madison","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Bupropion is a norepinephrine-dopamine reuptake inhibitor that increases levels of these neurotransmitters in the brain to reduce cravings and withdrawal symptoms during smoking cessation. Used for Smoking cessation aid.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}