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Active bupropion + counseling
Bupropion inhibits the reuptake of dopamine and norepinephrine in the central nervous system, increasing their availability to enhance mood and motivation, while counseling provides behavioral support for smoking cessation or other psychiatric conditions.
Bupropion inhibits the reuptake of dopamine and norepinephrine in the central nervous system, increasing their availability to enhance mood and motivation, while counseling provides behavioral support for smoking cessation or other psychiatric conditions. Used for Smoking cessation (with behavioral counseling), Major depressive disorder, Seasonal affective disorder.
At a glance
| Generic name | Active bupropion + counseling |
|---|---|
| Sponsor | University of Wisconsin, Madison |
| Drug class | Antidepressant (dopamine-norepinephrine reuptake inhibitor) |
| Target | Dopamine transporter (DAT), Norepinephrine transporter (NET) |
| Modality | Small molecule |
| Therapeutic area | Psychiatry / Addiction Medicine |
| Phase | FDA-approved |
Mechanism of action
Bupropion is an atypical antidepressant that works primarily as a dopamine and norepinephrine reuptake inhibitor (DNRI), distinct from serotonin-focused mechanisms. When combined with counseling, the pharmacological effects are augmented by behavioral intervention, addressing both neurochemical and psychological aspects of the condition. This combination approach is particularly effective for smoking cessation and depression management.
Approved indications
- Smoking cessation (with behavioral counseling)
- Major depressive disorder
- Seasonal affective disorder
Common side effects
- Insomnia
- Dry mouth
- Nausea
- Headache
- Dizziness
- Seizures
Key clinical trials
- The Precision CAD Trial (NA)
- PARQuit Smoking Cessation Intervention for Adults With Serious Mental Illness (PHASE4)
- Trial of Integrated Smoking Cessation, Exercise and Weight Management in Serious Mental Illness: TRIUMPH (NA)
- Pharmacological and Behavioral Treatment After Bariatric Surgery (PHASE2, PHASE3)
- Assessment of and Treatment Applied to Food Addiction in a Rural Healthy Behaviors Clinic (PHASE4)
- Effectiveness of Combined Tobacco Treatment in Hospitalized Subjects (PHASE4)
- Abstinence Reinforcement Therapy (ART) for Homeless Veteran Smokers (PHASE4)
- So-Lo-Mo Intervention Applied to the Smoking Cessation Process (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Active bupropion + counseling CI brief — competitive landscape report
- Active bupropion + counseling updates RSS · CI watch RSS
- University of Wisconsin, Madison portfolio CI