{"id":"active-bupropion-counseling","safety":{"commonSideEffects":[{"rate":"30-40","effect":"Insomnia"},{"rate":"17-24","effect":"Dry mouth"},{"rate":"13-18","effect":"Nausea"},{"rate":"26","effect":"Headache"},{"rate":"11","effect":"Dizziness"},{"rate":"0.4","effect":"Seizures"}]},"_chembl":{"chemblId":"CHEMBL1201735","moleculeType":"Small molecule","molecularWeight":"320.66"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Bupropion is an atypical antidepressant that works primarily as a dopamine and norepinephrine reuptake inhibitor (DNRI), distinct from serotonin-focused mechanisms. When combined with counseling, the pharmacological effects are augmented by behavioral intervention, addressing both neurochemical and psychological aspects of the condition. This combination approach is particularly effective for smoking cessation and depression management.","oneSentence":"Bupropion inhibits the reuptake of dopamine and norepinephrine in the central nervous system, increasing their availability to enhance mood and motivation, while counseling provides behavioral support for smoking cessation or other psychiatric conditions.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:17:34.309Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Smoking cessation (with behavioral counseling)"},{"name":"Major depressive disorder"},{"name":"Seasonal affective disorder"}]},"trialDetails":[{"nctId":"NCT04755413","phase":"NA","title":"The Precision CAD Trial","status":"ACTIVE_NOT_RECRUITING","sponsor":"Emory University","startDate":"2022-10-19","conditions":"Coronary Artery Disease","enrollment":276},{"nctId":"NCT03950427","phase":"PHASE4","title":"PARQuit Smoking Cessation Intervention for Adults With Serious Mental Illness","status":"COMPLETED","sponsor":"University of California, San Francisco","startDate":"2019-07-08","conditions":"Smoking Cessation, Smoking, Tobacco, Mental Illness","enrollment":131},{"nctId":"NCT02424188","phase":"NA","title":"Trial of Integrated Smoking Cessation, Exercise and Weight Management in Serious Mental Illness: TRIUMPH","status":"COMPLETED","sponsor":"Johns Hopkins University","startDate":"2016-07-07","conditions":"Mental Illness","enrollment":192},{"nctId":"NCT05157698","phase":"PHASE2, PHASE3","title":"Pharmacological and Behavioral Treatment After Bariatric Surgery","status":"RECRUITING","sponsor":"Yale University","startDate":"2022-01-13","conditions":"Obesity","enrollment":160},{"nctId":"NCT03431831","phase":"PHASE4","title":"Assessment of and Treatment Applied to Food Addiction in a Rural Healthy Behaviors Clinic","status":"COMPLETED","sponsor":"University of Nebraska","startDate":"2017-07-01","conditions":"Obesity","enrollment":86},{"nctId":"NCT06254001","phase":"PHASE4","title":"Effectiveness of Combined Tobacco Treatment in Hospitalized Subjects","status":"RECRUITING","sponsor":"National Institute of Respiratory Diseases, Mexico","startDate":"2024-01-15","conditions":"Tobacco Smoking, Tobacco Withdrawal, Nicotine Addiction","enrollment":134},{"nctId":"NCT02245308","phase":"PHASE4","title":"Abstinence Reinforcement Therapy (ART) for Homeless Veteran Smokers","status":"COMPLETED","sponsor":"VA Office of Research and Development","startDate":"2014-10-01","conditions":"Tobacco Use Disorder, Homelessness","enrollment":133},{"nctId":"NCT03553173","phase":"NA","title":"So-Lo-Mo Intervention Applied to the Smoking Cessation Process","status":"COMPLETED","sponsor":"Fundación Pública Andaluza para la gestión de la Investigación en Sevilla","startDate":"2016-10-24","conditions":"Smoking Cessation, Health Behavior, Lifestyle-related Condition","enrollment":240},{"nctId":"NCT02744417","phase":"NA","title":"Effect of Smoking Cessation on Clinical and Microbiological Outcomes of the Non-surgical Periodontal Therapy","status":"COMPLETED","sponsor":"Claudio Mendes Pannuti","startDate":"2010-08","conditions":"Periodontitis","enrollment":63},{"nctId":"NCT02873754","phase":"NA","title":"Smoking Treatment and Exercise Program for Underserved Populations (STEP UP)","status":"COMPLETED","sponsor":"Duke University","startDate":"2017-01","conditions":"Smoking","enrollment":11},{"nctId":"NCT00285584","phase":"PHASE1","title":"Bupropion For Reducing High-Risk Behaviors in Depressed Men Who Have Sex With Men (MSM)","status":"COMPLETED","sponsor":"NYU Langone Health","startDate":"2002-09","conditions":"HIV Infections, Depression","enrollment":41},{"nctId":"NCT01621009","phase":"PHASE4","title":"Bupropion SR Plus Counseling for Smoking Cessation","status":"COMPLETED","sponsor":"University of Wisconsin, Madison","startDate":"2001-01","conditions":"Tobacco Dependence, Smoking","enrollment":463}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":49,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Active bupropion + counseling","genericName":"Active bupropion + counseling","companyName":"University of Wisconsin, Madison","companyId":"university-of-wisconsin-madison","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Bupropion inhibits the reuptake of dopamine and norepinephrine in the central nervous system, increasing their availability to enhance mood and motivation, while counseling provides behavioral support for smoking cessation or other psychiatric conditions. Used for Smoking cessation (with behavioral counseling), Major depressive disorder, Seasonal affective disorder.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}