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Actimmune Registry
Interferon gamma-1b is a recombinant form of the human interferon gamma protein that helps to stimulate the immune system to fight infections and diseases.
Interferon gamma-1b is a recombinant form of the human interferon gamma protein that helps to stimulate the immune system to fight infections and diseases. Used for Severe malignant osteopetrosis, Severe chronic granulomatous disease, Severe congenital neutropenia.
At a glance
| Generic name | Actimmune Registry |
|---|---|
| Sponsor | InterMune |
| Drug class | Interferon |
| Target | IFN-gamma receptor |
| Modality | Small molecule |
| Therapeutic area | Immunology |
| Phase | Phase 2 |
Mechanism of action
Interferon gamma-1b works by activating immune cells called macrophages and natural killer cells, which help to destroy infected cells and tumor cells. This leads to an increase in the production of other immune molecules that help to fight infections and diseases.
Approved indications
- Severe malignant osteopetrosis
- Severe chronic granulomatous disease
- Severe congenital neutropenia
Common side effects
- Flu-like symptoms
- Injection site reactions
- Fatigue
- Headache
- Muscle pain
Key clinical trials
- The 1st Tumor CytokinoTherapy Database (TCTD-1)
- Post Marketing Surveillance Study of Actimmune in Patients With Severe, Malignant Osteopetrosis
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |