{"id":"actimmune-registry","safety":{"commonSideEffects":[{"rate":"50-70%","effect":"Flu-like symptoms"},{"rate":"30-50%","effect":"Injection site reactions"},{"rate":"20-40%","effect":"Fatigue"},{"rate":"20-40%","effect":"Headache"},{"rate":"10-30%","effect":"Muscle pain"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Interferon gamma-1b works by activating immune cells called macrophages and natural killer cells, which help to destroy infected cells and tumor cells. This leads to an increase in the production of other immune molecules that help to fight infections and diseases.","oneSentence":"Interferon gamma-1b is a recombinant form of the human interferon gamma protein that helps to stimulate the immune system to fight infections and diseases.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T03:18:53.600Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Severe malignant osteopetrosis"},{"name":"Severe chronic granulomatous disease"},{"name":"Severe congenital neutropenia"}]},"trialDetails":[{"nctId":"NCT06222801","phase":"","title":"The 1st Tumor CytokinoTherapy Database (TCTD-1)","status":"RECRUITING","sponsor":"OncoCareClinic 308 Ltd","startDate":"2022-09-19","conditions":"Oncology","enrollment":5000},{"nctId":"NCT00043329","phase":"","title":"Post Marketing Surveillance Study of Actimmune in Patients With Severe, Malignant Osteopetrosis","status":"COMPLETED","sponsor":"InterMune","startDate":"2002-01","conditions":"Osteopetrosis","enrollment":6}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_2","status":"active","brandName":"Actimmune Registry","genericName":"Actimmune Registry","companyName":"InterMune","companyId":"intermune","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Interferon gamma-1b is a recombinant form of the human interferon gamma protein that helps to stimulate the immune system to fight infections and diseases. Used for Severe malignant osteopetrosis, Severe chronic granulomatous disease, Severe congenital neutropenia.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}