Last reviewed · How we verify
Acetaminophen (paracetamol)
Acetaminophen (paracetamol) is a Analgesic and antipyretic Small molecule drug developed by Hellenic Society of Hematology. It is currently FDA-approved for Mild to moderate pain, Fever reduction. Also known as: Tylenol®.
Acetaminophen reduces pain and fever by inhibiting prostaglandin synthesis in the central nervous system.
Acetaminophen reduces pain and fever by inhibiting prostaglandin synthesis in the central nervous system. Used for Mild to moderate pain, Fever reduction.
At a glance
| Generic name | Acetaminophen (paracetamol) |
|---|---|
| Also known as | Tylenol® |
| Sponsor | Hellenic Society of Hematology |
| Drug class | Analgesic and antipyretic |
| Target | Cyclooxygenase (COX), primarily central nervous system isoforms |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | FDA-approved |
Mechanism of action
Acetaminophen is believed to work primarily through inhibition of cyclooxygenase (COX) enzymes in the brain and spinal cord, reducing prostaglandin production and thereby lowering the pain threshold and resetting the hypothalamic thermostat. Unlike NSAIDs, it has minimal peripheral anti-inflammatory effects and does not significantly inhibit COX in peripheral tissues, which accounts for its different safety profile.
Approved indications
- Mild to moderate pain
- Fever reduction
Common side effects
- Hepatotoxicity (at overdose)
- Rash
- Nausea
Key clinical trials
- Examining Analgesic Synergy and Efficacy in Trauma Care (PHASE4)
- A Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Triple-Negative Breast Cancer (MK-2870-011/TroFuse-011) (PHASE3)
- A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032) (PHASE3)
- Sacituzumab Tirumotecan (MK-2870) Versus Pemetrexed and Carboplatin Combination Therapy in Participants With Epidermal Growth Factor (EGFR)-Mutated, Advanced Nonsquamous Non-small Cell Lung Cancer (NSCLC) Who Have Progressed on Prior EGFR Tyrosine Kinase Inhibitors (MK-2870-009) (PHASE3)
- A Study to Evaluate the Efficacy and Safety of Sacituzumab Tirumotecan (MK-2870) Maintenance Treatment Versus Standard of Care in Participants With Platinum-sensitive Recurrent Ovarian Cancer (MK-2870-022/TroFuse-022/ENGOT-ov84/GOG-3103) (PHASE3)
- Evaluation of Broccoli Seed and Sprout Extract for Detoxification of Carcinogens in Firefighters (PHASE2)
- A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019) (PHASE3)
- A Clinical Trial of Sac-TMT in People With Non-HRD Positive Advanced Ovarian Cancer (MK-2870-021) (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Acetaminophen (paracetamol) CI brief — competitive landscape report
- Acetaminophen (paracetamol) updates RSS · CI watch RSS
- Hellenic Society of Hematology portfolio CI
Frequently asked questions about Acetaminophen (paracetamol)
What is Acetaminophen (paracetamol)?
How does Acetaminophen (paracetamol) work?
What is Acetaminophen (paracetamol) used for?
Who makes Acetaminophen (paracetamol)?
Is Acetaminophen (paracetamol) also known as anything else?
What drug class is Acetaminophen (paracetamol) in?
What development phase is Acetaminophen (paracetamol) in?
What are the side effects of Acetaminophen (paracetamol)?
What does Acetaminophen (paracetamol) target?
Related
- Drug class: All Analgesic and antipyretic drugs
- Target: All drugs targeting Cyclooxygenase (COX), primarily central nervous system isoforms
- Manufacturer: Hellenic Society of Hematology — full pipeline
- Therapeutic area: All drugs in Pain Management
- Indication: Drugs for Mild to moderate pain
- Indication: Drugs for Fever reduction
- Also known as: Tylenol®
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing