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Acetaminophen, ketoprofen, morphine
This is a fixed-dose combination of three analgesics/antipyretics that work through different mechanisms: acetaminophen inhibits prostaglandin synthesis, ketoprofen blocks COX enzymes, and morphine acts as an opioid receptor agonist.
This is a fixed-dose combination of three analgesics/antipyretics that work through different mechanisms: acetaminophen inhibits prostaglandin synthesis, ketoprofen blocks COX enzymes, and morphine acts as an opioid receptor agonist. Used for Moderate to severe pain.
At a glance
| Generic name | Acetaminophen, ketoprofen, morphine |
|---|---|
| Also known as | dolipraneoro 500mg, MA 352 120-2, bi profenid LP 100 mg, MA 399804-5, Actiskenan 10 mg, MA 561958-9 |
| Sponsor | University Hospital, Montpellier |
| Drug class | Analgesic combination (acetaminophen + NSAID + opioid) |
| Target | Prostaglandin synthesis (acetaminophen), COX-1/COX-2 (ketoprofen), mu opioid receptor (morphine) |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | FDA-approved |
Mechanism of action
Acetaminophen reduces pain and fever by inhibiting prostaglandin synthesis in the central nervous system. Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce inflammation and pain. Morphine is an opioid agonist that binds to mu opioid receptors in the central and peripheral nervous systems to provide potent analgesia. The combination provides multimodal pain relief.
Approved indications
- Moderate to severe pain
Common side effects
- Nausea
- Constipation
- Dizziness
- Gastrointestinal upset
- Respiratory depression
Key clinical trials
- Comparison of Two Pain-treatment Techniques After Cesarean Section (PHASE4)
- TAP vs QLB in Patients After Cesarean Delivery (PHASE4)
- Nonopioid Analgesics and Cholecystectomy (PHASE3)
- Erector Spinae Block vs Morphine in Vertebral Fixation (NA)
- Effect of Bilateral Transversus Thoracis Muscle Plane Block in Patients Undergoing Coronary Artery Bypass Graft Surgery.
- Regional Analgesia After Cesarean Section (PHASE4)
- Interfascial Infiltration for Acute Unspecific Low Back Pain in the Emergency Department
- Trauma Acute Pain Treatment With Methoxyflurane Vaporized (PENTHROX®): Efficacy and Safety Study (MEDITA) (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |