{"id":"acetaminophen-ketoprofen-morphine","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Constipation"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Respiratory depression"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Acetaminophen reduces pain and fever by inhibiting prostaglandin synthesis in the central nervous system. Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce inflammation and pain. Morphine is an opioid agonist that binds to mu opioid receptors in the central and peripheral nervous systems to provide potent analgesia. The combination provides multimodal pain relief.","oneSentence":"This is a fixed-dose combination of three analgesics/antipyretics that work through different mechanisms: acetaminophen inhibits prostaglandin synthesis, ketoprofen blocks COX enzymes, and morphine acts as an opioid receptor agonist.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:42:02.709Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Moderate to severe pain"}]},"trialDetails":[{"nctId":"NCT02804126","phase":"PHASE4","title":"Comparison of Two Pain-treatment Techniques After Cesarean Section","status":"COMPLETED","sponsor":"Michał Borys","startDate":"2017-06-01","conditions":"Cesarean Section, Pain Management, Neuropathic Pain","enrollment":232},{"nctId":"NCT03404908","phase":"PHASE4","title":"TAP vs QLB in Patients After Cesarean Delivery","status":"COMPLETED","sponsor":"Medical University of Lublin","startDate":"2018-02-07","conditions":"Cesarean Section, Postoperative Pain","enrollment":105},{"nctId":"NCT04622813","phase":"PHASE3","title":"Nonopioid Analgesics and Cholecystectomy","status":"COMPLETED","sponsor":"American University of Beirut Medical Center","startDate":"2021-04-08","conditions":"Cholecystectomy, Pain, Postoperative, Opioid Use","enrollment":90},{"nctId":"NCT04729049","phase":"NA","title":"Erector Spinae Block vs Morphine in Vertebral Fixation","status":"COMPLETED","sponsor":"AUSL Romagna Rimini","startDate":"2021-02-01","conditions":"Vertebral Subluxation, Spine Disease, Spondylolisthesis","enrollment":30},{"nctId":"NCT04849117","phase":"","title":"Effect of Bilateral Transversus Thoracis Muscle Plane Block in Patients Undergoing Coronary Artery Bypass Graft Surgery.","status":"COMPLETED","sponsor":"University Hospital, Montpellier","startDate":"2018-01-01","conditions":"Coronary Artery Disease, Pain Syndrome","enrollment":100},{"nctId":"NCT03244540","phase":"PHASE4","title":"Regional Analgesia After Cesarean Section","status":"COMPLETED","sponsor":"Medical University of Lublin","startDate":"2017-09-04","conditions":"Cesarean Section, Pain, Postoperative, Pain, Neuropathic","enrollment":105},{"nctId":"NCT03968185","phase":"","title":"Interfascial Infiltration for Acute Unspecific Low Back Pain in the Emergency Department","status":"COMPLETED","sponsor":"University Hospital, Montpellier","startDate":"2017-04-01","conditions":"Low Back Pain, Acute","enrollment":30},{"nctId":"NCT03585374","phase":"PHASE3","title":"Trauma Acute Pain Treatment With Methoxyflurane Vaporized (PENTHROX®): Efficacy and Safety Study (MEDITA)","status":"COMPLETED","sponsor":"Mundipharma Pharmaceuticals srl","startDate":"2018-02-08","conditions":"Acute Traumatic Pain","enrollment":272},{"nctId":"NCT01882530","phase":"PHASE4","title":"Non-opioid Analgesic Combination With Morphine for Postoperative Analgesia.","status":"TERMINATED","sponsor":"Rennes University Hospital","startDate":"2013-07-23","conditions":"Post Operative Analgesia","enrollment":223},{"nctId":"NCT02248493","phase":"PHASE4","title":"Intravenous Paracetamol for Postoperative Pain","status":"COMPLETED","sponsor":"Lithuanian University of Health Sciences","startDate":"2012-11","conditions":"Pain, Postoperative, Recovery of Function, Child","enrollment":54},{"nctId":"NCT01566253","phase":"PHASE4","title":"Oral Self Medication Versus IV Administration of Pain Killers After Caesarian Delivery","status":"COMPLETED","sponsor":"University Hospital, Montpellier","startDate":"2012-03","conditions":"Caesarian Section","enrollment":80}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":68,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["dolipraneoro 500mg, MA 352 120-2","bi profenid LP 100 mg, MA 399804-5","Actiskenan 10 mg, MA 561958-9"],"phase":"marketed","status":"active","brandName":"Acetaminophen, ketoprofen, morphine","genericName":"Acetaminophen, ketoprofen, morphine","companyName":"University Hospital, Montpellier","companyId":"university-hospital-montpellier","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This is a fixed-dose combination of three analgesics/antipyretics that work through different mechanisms: acetaminophen inhibits prostaglandin synthesis, ketoprofen blocks COX enzymes, and morphine acts as an opioid receptor agonist. Used for Moderate to severe pain.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}