Last reviewed · How we verify
Aceclidine ophthalmic solution
Aceclidine ophthalmic solution is a Muscarinic receptor agonist Small molecule drug developed by LENZ Therapeutics, Inc. It is currently in Phase 3 development for Presbyopia (age-related loss of accommodation), Potentially glaucoma or ocular hypertension. Also known as: LNZ100, Aceclidine.
Aceclidine is a cholinergic agonist that stimulates muscarinic receptors in the eye to increase accommodation and improve near vision.
Aceclidine is a cholinergic agonist that stimulates muscarinic receptors in the eye to increase accommodation and improve near vision. Used for Presbyopia (age-related loss of accommodation), Potentially glaucoma or ocular hypertension.
At a glance
| Generic name | Aceclidine ophthalmic solution |
|---|---|
| Also known as | LNZ100, Aceclidine |
| Sponsor | LENZ Therapeutics, Inc |
| Drug class | Muscarinic receptor agonist |
| Target | Muscarinic acetylcholine receptors (M1, M3) |
| Modality | Small molecule |
| Therapeutic area | Ophthalmology |
| Phase | Phase 3 |
Mechanism of action
Aceclidine works by activating muscarinic acetylcholine receptors on the ciliary muscle and iris sphincter in the eye. This parasympathomimetic action causes contraction of the ciliary muscle (accommodation) and pupil constriction, which can improve near vision and potentially reduce intraocular pressure. The ophthalmic solution formulation allows direct local delivery to ocular tissues.
Approved indications
- Presbyopia (age-related loss of accommodation)
- Potentially glaucoma or ocular hypertension
Common side effects
- Ocular discomfort or irritation
- Blurred vision
- Headache
- Brow ache
Key clinical trials
- Phase 3 Efficacy Study of LNZ100 & LNZ101 for the Treatment of Presbyopia (PHASE3)
- Phase 3 Evaluation of the Safety and Efficacy of LNZ100 & LNZ101 for the Treatment of Presbyopia (PHASE3)
- Evaluation of the Efficacy and Safety of LNZ101 and LNZ100 for the Presbyopia (PHASE3)
- Phase 3 Safety Study for the Treatment of Presbyopia Subjects (PHASE3)
- Evaluation of the Safety and Effectiveness of Aceclidine (LNZ101) and Aceclidine + Brimonidine (LNZ100) in the Treatment of Presbyopia (PHASE2)
- Evaluation of the Safety and Effectiveness of Aceclidine/Brimonidine (LNZ101) and Aceclidine (LNZ100) in the Treatment of Presbyopia (PHASE2)
- Safety, Tolerability and Pharmacokinetics of LNZ101 and LNZ100 Ophthalmic Solutions in Healthy Adult Chinese With Presbyopia (PHASE1)
- Plasma Pharmacokinetics and Safety of LNZ101 and LNZ100 Ophthalmic Solutions in Healthy Adult Subjects With Presbyopia (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Aceclidine ophthalmic solution CI brief — competitive landscape report
- Aceclidine ophthalmic solution updates RSS · CI watch RSS
- LENZ Therapeutics, Inc portfolio CI
Frequently asked questions about Aceclidine ophthalmic solution
What is Aceclidine ophthalmic solution?
How does Aceclidine ophthalmic solution work?
What is Aceclidine ophthalmic solution used for?
Who makes Aceclidine ophthalmic solution?
Is Aceclidine ophthalmic solution also known as anything else?
What drug class is Aceclidine ophthalmic solution in?
What development phase is Aceclidine ophthalmic solution in?
What are the side effects of Aceclidine ophthalmic solution?
What does Aceclidine ophthalmic solution target?
Related
- Drug class: All Muscarinic receptor agonist drugs
- Target: All drugs targeting Muscarinic acetylcholine receptors (M1, M3)
- Manufacturer: LENZ Therapeutics, Inc — full pipeline
- Therapeutic area: All drugs in Ophthalmology
- Indication: Drugs for Presbyopia (age-related loss of accommodation)
- Indication: Drugs for Potentially glaucoma or ocular hypertension
- Also known as: LNZ100, Aceclidine
- Compare: Aceclidine ophthalmic solution vs similar drugs
- Pricing: Aceclidine ophthalmic solution cost, discount & access