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Accordion Pill™ Carbidopa/Levodopa
The Accordion Pill™ is a modified-release formulation that delivers carbidopa and levodopa sequentially to optimize absorption and reduce motor fluctuations in Parkinson's disease.
The Accordion Pill™ is a modified-release formulation that delivers carbidopa and levodopa sequentially to optimize absorption and reduce motor fluctuations in Parkinson's disease. Used for Parkinson's disease with motor fluctuations.
At a glance
| Generic name | Accordion Pill™ Carbidopa/Levodopa |
|---|---|
| Also known as | AP CD/LD, AP-CD/LD |
| Sponsor | Intec Pharma Ltd. |
| Drug class | Dopamine precursor with peripheral decarboxylase inhibitor |
| Target | Aromatic L-amino acid decarboxylase (carbidopa); dopamine pathway (levodopa) |
| Modality | Small molecule |
| Therapeutic area | Neurology |
| Phase | Phase 3 |
Mechanism of action
Levodopa is converted to dopamine in the brain to replace depleted neurotransmitter in Parkinson's disease, while carbidopa inhibits peripheral decarboxylation of levodopa, allowing more to reach the brain. The Accordion Pill's accordion-shaped design expands in the stomach and releases the drugs in a controlled, sequential manner to maintain more stable plasma levels and reduce on-off motor symptoms.
Approved indications
- Parkinson's disease with motor fluctuations
Common side effects
- Nausea
- Dyskinesia
- Dizziness
- Orthostatic hypotension
Key clinical trials
- A Study to Assess the Safety and Efficacy of the of the Gastric-retentive AP-CD/LD in Advanced Parkinson's Patients (PHASE3)
- A Study of AP-CD/LD in Fluctuating Parkinson's Disease Patients Who Completed IN 11 004 (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Accordion Pill™ Carbidopa/Levodopa CI brief — competitive landscape report
- Accordion Pill™ Carbidopa/Levodopa updates RSS · CI watch RSS
- Intec Pharma Ltd. portfolio CI