{"id":"accordion-pill-carbidopa-levodopa","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Dyskinesia"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Orthostatic hypotension"}]},"_chembl":{"chemblId":"CHEMBL1200748","moleculeType":"Small molecule","molecularWeight":"244.25"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Levodopa is converted to dopamine in the brain to replace depleted neurotransmitter in Parkinson's disease, while carbidopa inhibits peripheral decarboxylation of levodopa, allowing more to reach the brain. The Accordion Pill's accordion-shaped design expands in the stomach and releases the drugs in a controlled, sequential manner to maintain more stable plasma levels and reduce on-off motor symptoms.","oneSentence":"The Accordion Pill™ is a modified-release formulation that delivers carbidopa and levodopa sequentially to optimize absorption and reduce motor fluctuations in Parkinson's disease.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:58:42.679Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Parkinson's disease with motor fluctuations"}]},"trialDetails":[{"nctId":"NCT02605434","phase":"PHASE3","title":"A Study to Assess the Safety and Efficacy of the of the Gastric-retentive AP-CD/LD in Advanced Parkinson's Patients","status":"UNKNOWN","sponsor":"Intec Pharma Ltd.","startDate":"2016-03","conditions":"Parkinson's Disease","enrollment":420},{"nctId":"NCT02615873","phase":"PHASE3","title":"A Study of AP-CD/LD in Fluctuating Parkinson's Disease Patients Who Completed IN 11 004","status":"UNKNOWN","sponsor":"Intec Pharma Ltd.","startDate":"2016-07","conditions":"Parkinson's Disease","enrollment":460}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["AP CD/LD","AP-CD/LD"],"phase":"phase_3","status":"active","brandName":"Accordion Pill™ Carbidopa/Levodopa","genericName":"Accordion Pill™ Carbidopa/Levodopa","companyName":"Intec Pharma Ltd.","companyId":"intec-pharma-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"The Accordion Pill™ is a modified-release formulation that delivers carbidopa and levodopa sequentially to optimize absorption and reduce motor fluctuations in Parkinson's disease. Used for Parkinson's disease with motor fluctuations.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}