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(1) Paracetamol injection
Paracetamol inhibits prostaglandin synthesis by blocking cyclooxygenase enzymes in the central nervous system, reducing pain perception and fever.
Paracetamol inhibits prostaglandin synthesis by blocking cyclooxygenase enzymes in the central nervous system, reducing pain perception and fever. Used for Acute pain management, Fever reduction, Postoperative pain.
At a glance
| Generic name | (1) Paracetamol injection |
|---|---|
| Sponsor | Ain Shams University |
| Drug class | Analgesic and antipyretic |
| Target | Cyclooxygenase (COX-1, COX-2) |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | Phase 3 |
Mechanism of action
Paracetamol (acetaminophen) acts primarily as a weak inhibitor of COX-1 and COX-2 enzymes, with preferential central nervous system penetration. This reduces prostaglandin E2 production in the hypothalamus and other CNS regions, lowering the pain threshold and resetting the body's temperature set point. The intravenous formulation provides rapid systemic delivery for acute pain and fever management.
Approved indications
- Acute pain management
- Fever reduction
- Postoperative pain
Common side effects
- Hepatotoxicity
- Injection site reactions
- Nausea
- Vomiting
Key clinical trials
- Serratus Plane Block (SPB) Versus Capsaïcine Versus Botox-A for Chronic Neuropathic Pain in Post-mastectomy Syndrome (PHASE2)
- Jaw Muscle Pain Post Wisdom Molar Surgery (PHASE2)
- The Efficacy and Safety of Liposomal Bupivacaine for Transversus Abdominis Plane Block in Relieving Postoperative Pain After Laparoscopic Surgery (NA)
- The Efficacy and Safety of Liposomal Bupivacaine for Transversus Abdominis Plane Block in Relieving Postoperative Pain After Laparoscopic Surgery in Gynecologic Oncology (NA)
- Daratumumab in STK11 Mutated NSCLC (PHASE2)
- The Efficacy and Safety of Liposomal Bupivacaine for Rhomboid Intercostal Nerve Block in Relieving Postoperative Pain After Video-assisted Thoracoscopic Surgery (NA)
- Comparing the Safety and Effectiveness of Different Doses of Morphine Administered in Spinal Anethesia for Pain Relief After Hip Replacement Surgery (PHASE4)
- Evaluating Premedication Regimens (Methylprednisolone vs Dexamethasone-based) for the Prevention of Systemic and Injection Site Reactions to Motixafortide in Patients With Multiple Myeloma Undergoing Stem Cell Mobilization, PARADE Trial (PHASE4)
Primary sources
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| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |