{"id":"1-paracetamol-injection","safety":{"commonSideEffects":[{"rate":null,"effect":"Hepatotoxicity"},{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Vomiting"}]},"_chembl":{"chemblId":"CHEMBL2108760","moleculeType":"Unknown"},"_fixedAt":"2026-03-30T17:35:39.663912","_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Paracetamol (acetaminophen) acts primarily as a weak inhibitor of COX-1 and COX-2 enzymes, with preferential central nervous system penetration. This reduces prostaglandin E2 production in the hypothalamus and other CNS regions, lowering the pain threshold and resetting the body's temperature set point. The intravenous formulation provides rapid systemic delivery for acute pain and fever management.","oneSentence":"Paracetamol inhibits prostaglandin synthesis by blocking cyclooxygenase enzymes in the central nervous system, reducing pain perception and fever.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:55:55.393Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute pain management"},{"name":"Fever reduction"},{"name":"Postoperative pain"}]},"_fixedFields":["pubmed(7)"],"trialDetails":[{"nctId":"NCT06807164","phase":"PHASE2","title":"Serratus Plane Block (SPB) Versus Capsaïcine Versus Botox-A for Chronic Neuropathic Pain in Post-mastectomy Syndrome","status":"RECRUITING","sponsor":"Centre Oscar Lambret","startDate":"2026-03-31","conditions":"Post-Mastectomy Neuropathic Pain Syndrome","enrollment":123},{"nctId":"NCT07094542","phase":"PHASE2","title":"Jaw Muscle Pain Post Wisdom Molar 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