Last reviewed · How we verify
.02% Chlorohexidine Gluconate
Chlorhexidine gluconate is a broad-spectrum antimicrobial agent that disrupts bacterial cell membranes and denatures proteins, providing antiseptic and disinfectant effects.
Chlorhexidine gluconate is a broad-spectrum antimicrobial agent that disrupts bacterial cell membranes and denatures proteins, providing antiseptic and disinfectant effects. Used for Oral antiseptic rinse for plaque and gingivitis reduction, Antimicrobial oral rinse for periodontal disease prevention.
At a glance
| Generic name | .02% Chlorohexidine Gluconate |
|---|---|
| Also known as | Clorasept (ArRiyadh Pharmaceuticals, Riyadh, Saudi Arabia) |
| Sponsor | Riyadh Colleges of Dentistry and Pharmacy |
| Drug class | Antimicrobial/Antiseptic agent |
| Target | Bacterial cell membrane and proteins |
| Modality | Small molecule |
| Therapeutic area | Oral Health / Infection Prevention |
| Phase | FDA-approved |
Mechanism of action
Chlorhexidine gluconate works by binding to and disrupting the integrity of bacterial cell membranes, leading to leakage of cellular contents and cell death. It also denatures bacterial proteins and interferes with metabolic processes. At low concentrations (0.02%), it exhibits bacteriostatic properties, while higher concentrations are bactericidal against a wide range of gram-positive and gram-negative bacteria, fungi, and some viruses.
Approved indications
- Oral rinse for plaque and gingivitis prevention
- Antimicrobial oral care in dental settings
Common side effects
- Tooth staining
- Taste alteration
- Oral irritation
- Allergic contact dermatitis
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape: