{"id":"02-chlorohexidine-gluconate","safety":{"commonSideEffects":[{"rate":null,"effect":"Tooth staining"},{"rate":null,"effect":"Taste alteration"},{"rate":null,"effect":"Oral irritation"},{"rate":null,"effect":"Allergic contact dermatitis"}]},"_chembl":{"chemblId":"CHEMBL4297088","moleculeType":"Small molecule","molecularWeight":"897.77"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Chlorhexidine gluconate works by binding to and disrupting the integrity of bacterial cell membranes, leading to leakage of cellular contents and cell death. It also denatures bacterial proteins and interferes with metabolic processes. At low concentrations (0.02%), it exhibits bacteriostatic properties, while higher concentrations are bactericidal against a wide range of gram-positive and gram-negative bacteria, fungi, and some viruses.","oneSentence":"Chlorhexidine gluconate is a broad-spectrum antimicrobial agent that disrupts bacterial cell membranes and denatures proteins, providing antiseptic and disinfectant effects.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:23:31.287Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Oral rinse for plaque and gingivitis prevention"},{"name":"Antimicrobial oral care in dental settings"}]},"trialDetails":[{"nctId":"NCT02662374","phase":"PHASE4","title":"Oral Hygiene Regimen in Patients on HCT","status":"UNKNOWN","sponsor":"Riyadh Colleges of Dentistry and Pharmacy","startDate":"2015-09","conditions":"Oral Mucositis","enrollment":45}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Clorasept (ArRiyadh Pharmaceuticals, Riyadh, Saudi Arabia)"],"phase":"marketed","status":"active","brandName":".02% Chlorohexidine Gluconate","genericName":".02% Chlorohexidine Gluconate","companyName":"Riyadh Colleges of Dentistry and Pharmacy","companyId":"riyadh-colleges-of-dentistry-and-pharmacy","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Chlorhexidine gluconate is a broad-spectrum antimicrobial agent that disrupts bacterial cell membranes and denatures proteins, providing antiseptic and disinfectant effects. Used for Oral antiseptic rinse for plaque and gingivitis reduction, Antimicrobial oral rinse for periodontal disease prevention.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}