Pulmonary Arterial Hypertension — Patent Landscape

Aggregated US Orange Book patent estate across every approved drug for pulmonary arterial hypertension. 227 active patents protecting 6 drugs from 4+ originators. First major cliff: 2026. Daily refresh.

6
Approved drugs
227
Active US patents
62/100
Avg vulnerability
$3.2B
Annual revenue covered

Originators in Pulmonary Arterial Hypertension

Companies holding active patents on drugs approved for this indication. Click through to each company's full patent dashboard.

AstraZeneca 121 patents United Therap 80 patents Bayer 20 patents Gilead Sciences 6 patents

Cliff calendar — next 15 years

Patent expiries per year across all drugs treating pulmonary arterial hypertension. Each bar = one year. Y-axis scaled to peak year (51 patents).

17
26
25
27
51
28
24
29
41
30
11
31
15
34
5
35
16
36
16
37

Approved drugs ranked by patent estate

Drug Originator Active patents Avg vuln Revenue First cliff
Uptravi
SELEXIPAG
 AstraZeneca 104 63 — 2026-10-31
Remodulin
TREPROSTINIL
 United Therap 80 54 $2.0B 2027-05-14
Adempas
RIOCIGUAT
 Bayer 20 59 — 2026-12-04
Opsumit
MACITENTAN
 AstraZeneca 16 71 $1.2B 2026-09-11
Letairis
AMBRISENTAN
 Gilead Sciences 6 73 — 2027-12-11
Tracleer
BOSENTAN
 AstraZeneca 1 50 — 2027-12-28

Most attackable patents

Highest vulnerability scores in the indication — paragraph IV / IPR / design-around candidates.

Patent Drug Type Vuln Expiry
10946015 Opsumit method of use 93 2026-09-11
10946015 Opsumit method of use 93 2026-09-11
11357782 Remodulin method of use 93 2027-05-14
11357782 Remodulin method of use 93 2027-05-14
11357782 Remodulin method of use 93 2027-05-14
11357782 Remodulin method of use 93 2027-05-14
11357782 Remodulin method of use 93 2027-05-14
8268847 Opsumit method of use 88 2029-04-18
8268847 Opsumit method of use 88 2029-04-18
8658694 Remodulin method of use 83 2028-09-05

Strongest defences

Lowest vulnerability scores — pillars of the indication's IP fortress.

Patent Drug Type Vuln Expiry
8791122 Uptravi composition of matter 10 2030-08-01
8791122 Uptravi composition of matter 10 2030-08-01
8791122 Uptravi composition of matter 10 2030-08-01
8791122 Uptravi composition of matter 10 2030-08-01
8791122 Uptravi composition of matter 10 2030-08-01
8791122 Uptravi composition of matter 10 2030-08-01
8791122 Uptravi composition of matter 10 2030-08-01
8791122 Uptravi composition of matter 10 2030-08-01
8791122 Uptravi composition of matter 10 2030-08-01
9593066 Remodulin composition of matter 17 2028-12-15

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