Last reviewed · How we verify
Methotrexate Toxicity
Approved treatments
- Wellcovorin · Pfizer Japan Inc
- Fusilev · Spectrum Pharms
- Fusilev · Acrotech Biopharma
Fusilev works by bypassing the enzyme dihydrofolate reductase, allowing normal cell growth and DNA synthesis.
Clinical guidelines
- FDA label — any
Leucovorin calcium rescue is indicated after high dose methotrexate therapy in osteosarcoma. Leucovorin calcium is also indicated to diminish the toxicity and counteract the effects of impaired methotrexate elimination and of inadvertent overdoses of folic acid antagonists.
Competitive intelligence
For the full treatment-landscape CI brief — marketed leaders side-by-side, pipeline by phase, recent regulatory actions, sponsor landscape:
- Methotrexate Toxicity patent landscape — cliff calendar, originator estates, attackable patents
- Methotrexate Toxicity treatment landscape brief
- Methotrexate Toxicity treatment updates RSS
Frequently asked questions about Methotrexate Toxicity
What drugs treat Methotrexate Toxicity?
Tracked treatments include Wellcovorin, Fusilev.
What is the treatment for Methotrexate Toxicity?
Standard treatment for Methotrexate Toxicity includes Wellcovorin, Fusilev. See the treatment landscape page for first-line, second-line and salvage options.
What are the treatment guidelines for Methotrexate Toxicity?
FDA label publishes guidelines for Methotrexate Toxicity. 1 guideline references tracked.
Related
- Treatment landscape: Methotrexate Toxicity patent cliff · Methotrexate Toxicity CI report
- Treatment: Wellcovorin · Pfizer Japan Inc
- Treatment: Fusilev · Spectrum Pharms
- Treatment: Fusilev · Acrotech Biopharma
- All diseases: Browse the disease index · Disease landscape hub
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing