What are Pulmonary surfactant replacement therapy drugs?

Pulmonary surfactant replacement therapy drugs are pharmacologic agents that share a common mechanism (typically targeting N/A (surfactant mechanism)). 9 are currently marketed, with 5 more in clinical development.

What are the marketed Pulmonary surfactant replacement therapy drugs?

Marketed Pulmonary surfactant replacement therapy drugs include Poractant alfa (Curosurf®), Infasurf, Colace, Curosurf, Bolus surfactant, Lung lavage with surfactant.

Pulmonary surfactant replacement therapy

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

9 marketed 4 in Phase 3 1 in Phase 2

This page covers all Pulmonary surfactant replacement therapy drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting N/A (surfactant mechanism), Pulmonary surfactant (lipid and protein complex), Glucocorticoid receptor.

Targets

N/A (surfactant mechanism) · Pulmonary surfactant (lipid and protein complex) · Glucocorticoid receptor · Pulmonary surfactant (lipid-protein complex) · Pulmonary surfactant (phospholipid and protein complex)

Marketed (9)

Poractant alfa (Curosurf®) · Chiesi Farmaceutici S.p.A. · Respiratory/Neonatology
Poractant alfa is a natural pulmonary surfactant that reduces surface tension in the lungs and restores normal respiratory function in neonates with respiratory distress syndrome.
Infasurf · ONY · Respiratory
Colace · Generic (multiple manufacturers) · Hematology
Curosurf · Chiesi Usa Inc · Respiratory
Curosurf works by reducing the surface tension in the lungs, allowing for easier breathing and improving oxygenation.
Bolus surfactant · Zekai Tahir Burak Women's Health Research and Education Hospital · Neonatology / Respiratory
Bolus surfactant reduces surface tension in the lungs to improve gas exchange and respiratory function in neonates with respiratory distress syndrome.
Lung lavage with surfactant · Zekai Tahir Burak Women's Health Research and Education Hospital · Pulmonology / Respiratory
Lung lavage with surfactant mechanically removes proteinaceous material from the lungs while surfactant replacement improves alveolar function and gas exchange.
Poractant alfa instillation · Poznan University of Medical Sciences · Respiratory/Pulmonology
Poractant alfa is a natural pulmonary surfactant that replaces deficient or dysfunctional surfactant in the lungs to restore normal respiratory function.
Budesonide-Surfactant · China Medical University Hospital · Respiratory/Pulmonology
Budesonide is a corticosteroid that reduces airway inflammation, while the surfactant component improves drug delivery and reduces surface tension in the lungs.
Survanta · AbbVie · Respiratory

Phase 3 pipeline (4)

Poractant Alfa Intratracheal Suspension [Curosurf] · Hospital Clinic of Barcelona · Respiratory
Poractant alfa is a surfactant replacement therapy that helps to reduce the surface tension in the lungs, facilitating easier breathing.
Surfactant nebulisation · University of Zurich · Respiratory/Pulmonology
Surfactant nebulisation delivers pulmonary surfactant directly to the lungs via inhalation to improve gas exchange and reduce respiratory distress.
Aerosolized Calfactant · ONY · Respiratory/Pulmonology
Aerosolized calfactant is a pulmonary surfactant replacement therapy delivered directly to the lungs via inhalation to restore surfactant function and improve gas exchange.
Curosurf-Group1 · Ottawa Hospital Research Institute · Respiratory/Neonatology
Curosurf is a natural pulmonary surfactant that replaces deficient surfactant in the lungs to improve gas exchange and reduce surface tension in the alveoli.

Phase 2 pipeline (1)

Intratracheal administration of surfactant · Chiesi Poland Sp. z o.o. · Respiratory
Surfactant replacement therapy

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