Statin and cholesterol absorption inhibitor combination

This page covers all Statin and cholesterol absorption inhibitor combination drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting HMG-CoA reductase and NPC1L1 transporter, HMG-CoA reductase; NPC1L1 transporter.

Targets

HMG-CoA reductase and NPC1L1 transporter · HMG-CoA reductase; NPC1L1 transporter

Marketed (2)

• simvastatin and ezetimibe · UMC Utrecht · Cardiovascular
  Simvastatin inhibits cholesterol synthesis while ezetimibe blocks dietary cholesterol absorption, together reducing LDL cholesterol levels.
• Atorvastatin, Ezetimibe · Abant Izzet Baysal University · Cardiovascular
  Atorvastatin inhibits HMG-CoA reductase to lower LDL cholesterol, while ezetimibe blocks intestinal cholesterol absorption, providing dual lipid-lowering action.