Serine protease inhibitor

This page covers all Serine protease inhibitor drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Serine proteases (thrombin, factor Xa, kallikrein, trypsin), TMPRSS2 (Transmembrane Protease Serine 2), Kallikrein, plasmin, trypsin, and other serine proteases.

Targets

Serine proteases (thrombin, factor Xa, kallikrein, trypsin) · TMPRSS2 (Transmembrane Protease Serine 2) · Kallikrein, plasmin, trypsin, and other serine proteases · SERPINFB

Marketed (1)

• Nafamostat Mesilate · Chong Kun Dang Pharmaceutical · Anticoagulation / Hemostasis
  Nafamostat mesilate is a serine protease inhibitor that blocks multiple coagulation and inflammatory proteases to prevent thrombosis and inflammation.

Phase 3 pipeline (2)

• Camostat mesylate · Seoul National University Hospital · Infectious Disease / Virology
  Camostat mesylate is a serine protease inhibitor that blocks transmembrane protease serine 2 (TMPRSS2), preventing viral entry and reducing inflammatory protease activity.
• Aprotinin (inhaled) · Fundacion del Hospital Nacional de Paraplejicos para la Investigacion y la Integracion · Pulmonary/Respiratory
  Aprotinin is a serine protease inhibitor that blocks multiple coagulation and fibrinolytic enzymes to reduce bleeding and inflammation in the lungs.

Phase 2 pipeline (1)

• Elunate® · Hutchmed · Oncology
  Elunate is a small molecule inhibitor of the serine protease inhibitor, serpin family F member 5 (SERPINFB).