Second-generation cephalosporin

This page covers all Second-generation cephalosporin drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Penicillin-binding proteins (PBPs).

Targets

Penicillin-binding proteins (PBPs)

Marketed (5)

• Cefaclor Capsules · Fundacion Clinic per a la Recerca Biomédica · Infectious Disease
  Cefaclor is a second-generation cephalosporin antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins.
• I.V cefuroxime 750 mg*3/d for 2 days · Western Galilee Hospital-Nahariya · Infectious Disease
  Cefuroxime is a second-generation cephalosporin antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins.
• Cefmetazole (drug) · National Taiwan University Hospital · Infectious Disease
  Cefmetazole is a second-generation cephalosporin antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins.
• P.O cefuroxime 500 mgx2/d for 5 days · Western Galilee Hospital-Nahariya · Infectious Disease
  Cefuroxime is a second-generation cephalosporin antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins.
• Cefuroxime (750mg) I.V · Hospital Universitari Vall d'Hebron Research Institute · Infectious Disease
  Cefuroxime is a second-generation cephalosporin antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins.

Phase 3 pipeline (4)

• Continuous infusion of cefoxitin · Poitiers University Hospital · Infectious Disease
  Cefoxitin is a second-generation cephalosporin antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins.
• Loading bolus of cefoxitin · Poitiers University Hospital · Infectious Disease
  Cefoxitin is a second-generation cephalosporin antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins.
• Intermittent cefoxitin · Poitiers University Hospital · Infectious Disease
  Cefoxitin is a second-generation cephalosporin antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins.
• Comparator: cefotetan · Merck Sharp & Dohme LLC · Infectious Disease
  Cefotetan is a second-generation cephalosporin antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins.