What are Purine nucleoside analog drugs?

Purine nucleoside analog drugs are pharmacologic agents that share a common mechanism (typically targeting Ribonucleotide reductase; DNA incorporation). 3 are currently marketed, with 4 more in clinical development.

What are the marketed Purine nucleoside analog drugs?

Marketed Purine nucleoside analog drugs include Cladribine Tablets, Cladribine (CLAD), Fludarabine (FLU).

Purine nucleoside analog

3 marketed 3 in Phase 3 1 in Phase 2

This page covers all Purine nucleoside analog drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Ribonucleotide reductase; DNA incorporation, DNA (via deoxyadenosine analog incorporation), Ribonucleotide reductase, DNA polymerase.

Targets

Ribonucleotide reductase; DNA incorporation · DNA (via deoxyadenosine analog incorporation) · Ribonucleotide reductase, DNA polymerase · Ribonucleotide reductase; DNA synthesis · DNA

Marketed (3)

Cladribine Tablets · Keith Edwards, M.D. · Oncology; Immunology
Cladribine is a purine nucleoside analog that inhibits ribonucleotide reductase and gets incorporated into DNA, causing selective depletion of lymphocytes.
Cladribine (CLAD) · M.D. Anderson Cancer Center · Oncology
Cladribine is a purine nucleoside analog that is phosphorylated intracellularly and incorporated into DNA, causing strand breaks and apoptosis in lymphoid cells.
Fludarabine (FLU) · Nanfang Hospital, Southern Medical University · Oncology
Fludarabine is a purine analog that inhibits ribonucleotide reductase and DNA polymerase, leading to DNA strand breaks and apoptosis in rapidly dividing cells.

Phase 3 pipeline (3)

Cladribine High Dose · Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany · Oncology, Immunology
Cladribine is a purine nucleoside analog that depletes lymphocytes by being incorporated into DNA and causing strand breaks, leading to selective destruction of immune cells.
Cladribine Low Dose · Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany · Immunology
Cladribine is a purine nucleoside analog that depletes lymphocytes by inhibiting ribonucleotide reductase and inducing apoptosis in dividing cells.
Cladribine Pill · Haukeland University Hospital · Immunology; Oncology
Cladribine is a purine nucleoside analog that inhibits ribonucleotide reductase and gets incorporated into DNA, leading to selective depletion of lymphocytes.

Phase 2 pipeline (1)

2-chlorodeoxyadenosine · North American Consortium for Histiocytosis · Oncology
2-chlorodeoxyadenosine is a purine nucleoside analog that inhibits DNA synthesis.