What are Prostaglandin analogue drugs?

Prostaglandin analogue drugs are pharmacologic agents that share a common mechanism (typically targeting Prostaglandin E1 receptor (EP receptor)). 3 are currently marketed, with 6 more in clinical development.

What are the marketed Prostaglandin analogue drugs?

Marketed Prostaglandin analogue drugs include Misoprostol, per-oral tablets, Misoprostol (given vaginally), Misoprostol, modified-release pessary.

Prostaglandin analogue

3 marketed 4 in Phase 3 2 in Phase 2

This page covers all Prostaglandin analogue drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Prostaglandin E1 receptor (EP receptor), Prostaglandin F2α receptor, FP receptor.

Targets

Prostaglandin E1 receptor (EP receptor) · Prostaglandin F2α receptor · FP receptor

Marketed (3)

Misoprostol, per-oral tablets · Tampere University Hospital · Gastroenterology; Obstetrics
Misoprostol is a prostaglandin E1 analogue that binds to prostaglandin receptors to increase gastric mucus production and reduce gastric acid secretion.
Misoprostol (given vaginally) · Hawler Medical University · Obstetrics/Gynecology
Misoprostol is a prostaglandin E1 analogue that binds to prostaglandin receptors to increase uterine contractions and promote cervical ripening and dilation.
Misoprostol, modified-release pessary · Tampere University Hospital · Obstetrics
Misoprostol is a prostaglandin E1 analogue that binds to prostaglandin receptors to increase uterine contractions and promote cervical ripening and dilation.

Phase 3 pipeline (4)

Tafluprost ophthalmic solution 0.0015% · Santen Pharmaceutical Co., Ltd. · Ophthalmology
Tafluprost is a prostaglandin F2α analogue that reduces intraocular pressure by increasing uveoscleral outflow.
Xalatan®/DE-130A · Santen SAS · Ophthalmology
Xalatan is a prostaglandin analogue that reduces intraocular pressure by increasing uveoscleral outflow.
Preservative-Free Tafluprost or vehicle · Merck Sharp & Dohme LLC · Ophthalmology
Tafluprost is a prostaglandin F2α analogue that reduces intraocular pressure by increasing uveoscleral outflow.
Misotac® Sigma Pharmaceutical Industries · Ain Shams University · Gastroenterology
Misoprostol is a prostaglandin E1 analogue that protects the gastric mucosa and reduces acid secretion.

Phase 2 pipeline (2)

Bimatoprost Solution 2 · Allergan · Ophthalmology
Prostaglandin F2α analogue
Latanoprost Punctal Plug Delivery System · Mati Therapeutics Inc. · Ophthalmology
Latanoprost Punctal Plug Delivery System works by delivering latanoprost, a prostaglandin F2α analogue, directly to the eye to reduce intraocular pressure.