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Latanoprost Punctal Plug Delivery System
Latanoprost Punctal Plug Delivery System works by delivering latanoprost, a prostaglandin F2α analogue, directly to the eye to reduce intraocular pressure.
Latanoprost Punctal Plug Delivery System works by delivering latanoprost, a prostaglandin F2α analogue, directly to the eye to reduce intraocular pressure. Used for Treatment of glaucoma and ocular hypertension.
At a glance
| Generic name | Latanoprost Punctal Plug Delivery System |
|---|---|
| Sponsor | Mati Therapeutics Inc. |
| Drug class | Prostaglandin analogue |
| Target | Prostaglandin F2α receptor |
| Modality | Small molecule |
| Therapeutic area | Ophthalmology |
| Phase | Phase 2 |
Mechanism of action
This is achieved by using a punctal plug to release latanoprost, which then acts on the eye's trabecular meshwork to increase aqueous humor outflow and decrease intraocular pressure. This is particularly useful for patients with glaucoma or ocular hypertension.
Approved indications
- Treatment of glaucoma and ocular hypertension
Common side effects
- Conjunctival hyperemia
- Eye irritation
Key clinical trials
- A Phase 2 Single-Masked, Randomized Study of Latanoprost PPDS in Ocular Hypertension or Open-Angle Glaucoma (PHASE2)
- A Study of the L-PPDS With Adjunctive Xalatan® Eye Drops in Subjects With OH or OAG (PHASE2)
- A Dose Evaluation Study of the Effect of Plug Placement on the Efficacy and Safety of the Latanoprost Punctal Plug Delivery System (L-PPDS) in Subjects With Ocular Hypertension or Open-Angle Glaucoma (PHASE2)
- A Dose Evaluation Study for the Latanoprost Punctal Plug Delivery System (L-PPDS) in Subjects With Ocular Hypertension or Open-Angle Glaucoma (PHASE2)
- Study of the Effects of Artificial Tears on the Response to the Latanoprost Punctal Plug Delivery System in Subjects With Ocular Hypertension or Open-Angle Glaucoma (PHASE2)
- A Safety Study of the Latanoprost Punctal Plug Delivery System (L-PPDS) in Subjects With Ocular Hypertension or Open Angle Glaucoma (PHASE2)
- A Phase 2 Study of Punctal Placement of the Latanoprost Punctal Plug Delivery System (L-PPDS) (PHASE2)
- A Study Evaluating the Latanoprost Punctal Plug Delivery System (L-PPDS) in Subjects With Ocular Hypertension or Open-Angle Glaucoma (PHASE2)
Primary sources
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| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |