Combination therapy: sympathomimetic amine plus phytocannabinoid

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

4 marketed 1 in Phase 3

This page covers all Combination therapy: sympathomimetic amine plus phytocannabinoid drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Dopamine transporter, norepinephrine transporter (methylphenidate); CB1/CB2 receptors, 5-HT1A, TRPV1 (cannabidiol), CB1 receptor, CB2 receptor, CB1 receptor, CB2 receptor, TRPV1, 5-HT1A receptor.

Targets

Dopamine transporter, norepinephrine transporter (methylphenidate); CB1/CB2 receptors, 5-HT1A, TRPV1 (cannabidiol) · CB1 receptor, CB2 receptor · CB1 receptor, CB2 receptor, TRPV1, 5-HT1A receptor · CB1 receptor, CB2 receptor, 5-HT1A receptor, TRPV1 receptor (multi-target)

Marketed (4)

dl-Methylphenidate plus Cannabidiol · University of Florida · Psychiatry/Neurology
dl-Methylphenidate increases dopamine and norepinephrine availability in the central nervous system, while cannabidiol modulates endocannabinoid signaling and has anti-inflammatory properties.
Cannabis Sativa Oil · Fondation pour l'accueil et l'hébérement des personnes âgées · Pain management, Neurology, Immunology
Cannabis Sativa Oil contains phytocannabinoids (primarily THC and CBD) that interact with endocannabinoid receptors (CB1 and CB2) throughout the central and peripheral nervous systems.
Cannabis oil · Assaf-Harofeh Medical Center · Neurology, Pain Management, Oncology (supportive care)
Cannabis oil contains cannabinoids (primarily THC and CBD) that interact with endocannabinoid receptors (CB1 and CB2) throughout the central and peripheral nervous systems to modulate pain, inflammation, and other physiological processes.
Hemp · Thammasat University Hospital · Pain management, Neurology, Psychiatry
Hemp contains cannabinoids (primarily CBD and THC) that interact with endocannabinoid receptors and other molecular targets to produce anti-inflammatory, analgesic, and anxiolytic effects.

Phase 3 pipeline (1)

Cannabidiol (CBD) Oil Capsules · McMaster University · Neurology, Psychiatry, Immunology
Cannabidiol modulates endocannabinoid signaling and multiple non-cannabinoid receptors to produce anti-inflammatory, anxiolytic, and neuroprotective effects.

Patent intelligence

phytocannabinoid patent landscape — aggregated cliff calendar, attackable patents, originator estates