Last reviewed 2026-04-22 · How we verify

Hemp

Hemp contains cannabinoids (primarily CBD and THC) that interact with endocannabinoid receptors and other molecular targets to produce anti-inflammatory, analgesic, and anxiolytic effects.

Hemp contains cannabinoids (primarily CBD and THC) that interact with endocannabinoid receptors and other molecular targets to produce anti-inflammatory, analgesic, and anxiolytic effects. Used for Chronic pain, Anxiety disorders, Epilepsy (particularly CBD).

At a glance

Mechanism of action

Hemp-derived products modulate the endocannabinoid system through CB1 and CB2 receptor agonism, as well as through non-receptor mechanisms including serotonin receptor modulation and TRPV1 activation. These interactions reduce inflammation, modulate pain signaling, and affect mood and anxiety regulation. The therapeutic effects vary depending on the cannabinoid profile and ratio of active compounds.

Approved indications

• Chronic pain
• Anxiety disorders
• Epilepsy (particularly CBD)
• Chemotherapy-induced nausea and vomiting

Common side effects

• Dizziness
• Dry mouth
• Fatigue
• Altered appetite
• Cognitive effects (THC-dependent)

Key clinical trials

• A Clinical Trial of a Hemp-Derived, High Cannabidiol Product for Anxiety in Glioblastoma Patients (PHASE2)
• CBG/CBD Oil for Chemotherapy-Induced Peripheral Neuropathy (PHASE1)
• Plant Protein With Ashwagandha-Rhodiola for Sleep Quality (NA)
• Effects of Hemp-Derived Cannabinoids on Menopause Symptoms (PHASE2)
• Topical CBD Scar Healing Study (PHASE1)
• Sex Hormones Impact on Cannabis Response (NA)
• Cannabidiol and Alcohol Use Disorder Phenotypes (PHASE2)
• Clinical Trial on Agitation in Alzheimer's Dementia (PHASE2)

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.