Nucleoside analog antimetabolite

This page covers all Nucleoside analog antimetabolite drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting DNA polymerase; ribonucleotide reductase, DNA polymerase; incorporated into DNA, Ribonucleotide reductase; DNA incorporation.

Targets

DNA polymerase; ribonucleotide reductase · DNA polymerase; incorporated into DNA · Ribonucleotide reductase; DNA incorporation · DNA polymerase; deoxycytidine kinase · DNA polymerase; cytidine metabolism · DNA synthesis (cytidine analog) · Ribonucleotide reductase; DNA polymerase

Marketed (4)

• standard dose ARA-C · National Research Center for Hematology, Russia · Oncology
  ARA-C (cytarabine) is a cytidine analog that inhibits DNA synthesis by being incorporated into DNA and blocking chain elongation, leading to cell death.
• Cytosine Arabinoside · University of Rochester · Oncology
  Cytosine arabinoside is a nucleoside analog that inhibits DNA synthesis by being incorporated into DNA and blocking DNA polymerase, leading to cell death.
• Gemcitabine Injectable Product · Henan Cancer Hospital · Oncology
  Gemcitabine is a nucleoside analog that inhibits ribonucleotide reductase and gets incorporated into DNA, causing chain termination and cell death.
• AraC · University of California, San Diego · Oncology
  AraC (cytarabine) is a nucleoside analog that inhibits DNA synthesis by being incorporated into DNA and blocking chain elongation.

Phase 3 pipeline (3)

• Cytosin-Arabinosid · University of Ulm · Oncology
  Cytarabine (Cytosin-Arabinosid) is a nucleoside analog that inhibits DNA synthesis by being incorporated into DNA during the S phase of the cell cycle, leading to cell death.
• high dose cytarabine · International Extranodal Lymphoma Study Group (IELSG) · Oncology
  High-dose cytarabine is a nucleoside analog that inhibits DNA synthesis by being incorporated into DNA, leading to cell death in rapidly dividing cells.
• Gemcitabine alone · Intergroupe Francophone de Cancerologie Thoracique · Oncology
  Gemcitabine is a nucleoside analog that inhibits ribonucleotide reductase and gets incorporated into DNA, causing chain termination and cell death.