What are Morpholine antifungal drugs?

Morpholine antifungal drugs are pharmacologic agents that share a common mechanism (typically targeting Lanosterol 14α-demethylase (CYP51)). 4 are currently marketed, with 0 more in clinical development.

What are the marketed Morpholine antifungal drugs?

Marketed Morpholine antifungal drugs include Loceryl Nail Lacquer, Loceryl NL + Cosmetic varnish, Loceryl NL 15 months, Amorolfine (Antifungal).

Morpholine antifungal

4 marketed

This page covers all Morpholine antifungal drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Lanosterol 14α-demethylase (CYP51), Δ14-steroid reductase and Δ8→Δ7-isomerase (ergosterol biosynthesis pathway), Fungal sterol synthesis enzymes (Δ14-reductase, Δ8-Δ7-isomerase).

Targets

Lanosterol 14α-demethylase (CYP51) · Δ14-steroid reductase and Δ8→Δ7-isomerase (ergosterol biosynthesis pathway) · Fungal sterol synthesis enzymes (Δ14-reductase, Δ8-Δ7-isomerase)

Marketed (4)

Loceryl Nail Lacquer · Galderma R&D · Dermatology
Amorolfine inhibits fungal sterol synthesis by blocking lanosterol demethylase, disrupting the integrity of the fungal cell membrane.
Loceryl NL + Cosmetic varnish · Galderma R&D · Dermatology
Amorolfine is a morpholine antifungal that inhibits fungal sterol synthesis by blocking both Δ14-reductase and Δ8-Δ7-isomerase enzymes in the ergosterol biosynthesis pathway.
Loceryl NL 15 months · Galderma R&D · Dermatology
Amorolfine is a morpholine antifungal that inhibits fungal sterol synthesis by blocking both Δ14-reductase and Δ8-Δ7-isomerase enzymes in the ergosterol biosynthesis pathway.
Amorolfine (Antifungal) · Pierre Fabre Dermo Cosmetique · Dermatology / Infectious Disease
Amorolfine inhibits fungal sterol synthesis by blocking lanosterol demethylase, disrupting the integrity of the fungal cell membrane.