Macrocyclic lactone antiparasitic

This page covers all Macrocyclic lactone antiparasitic drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Glutamate-gated chloride channels (GluCl).

Targets

Glutamate-gated chloride channels (GluCl)

Marketed (1)

• Oral ivermectin · University of Oxford · Infectious Disease / Parasitology
  Ivermectin binds to glutamate-gated chloride channels in parasitic organisms, causing paralysis and death of the parasite.

Phase 3 pipeline (2)

• Ivermectin 400 µg/kg · Assistance Publique - Hôpitaux de Paris · Infectious Disease / Parasitology
  Ivermectin binds to glutamate-gated chloride channels in parasites and some insects, causing paralysis and death of the organism.
• Ivermectin on Day 1 · Lihir Medical Centre · Infectious Disease / Parasitology
  Ivermectin is a macrocyclic lactone that binds to glutamate-gated chloride channels in parasites, causing paralysis and death.