Echinocandin antifungal

This page covers all Echinocandin antifungal drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting β-1,3-glucan synthase (FKS), ATP-binding cassette sub-family G member 2, 1,3-beta-D-glucan synthase.

Targets

β-1,3-glucan synthase (FKS) · ATP-binding cassette sub-family G member 2 · 1,3-beta-D-glucan synthase · 1,3-β-D-glucan synthase · Beta-1,3-D-glucan synthase · β-1,3-glucan synthase (FKS1)

Marketed (5)

• PRA · Scynexis, Inc. · Infectious Disease
  PRA (prasifungin) is an antifungal agent that inhibits fungal cell wall synthesis by targeting glucan synthase.
• Cancidas · Merck & Co. · Infectious Disease
  Cancidas works by inhibiting the synthesis of beta-1,6-glucan, a critical component of the fungal cell wall.
• Eraxis · Vicuron Holdings · Infectious Disease
  Eraxis works by inhibiting the synthesis of beta-1,3-D-glucan, a critical component of the fungal cell wall.
• Mycamine · Teva Pharms Usa Inc · Infectious Disease
• Eraxis (anidulafungin) · Pfizer · Infectious Disease
  Anidulafungin inhibits fungal cell wall synthesis by blocking the enzyme glucan synthase, leading to fungal cell death.

Phase 3 pipeline (5)

• FK463 · Astellas Pharma Inc · Infectious Disease
  FK463 is a fungal cell wall synthesis inhibitor that disrupts β-glucan formation, leading to fungal cell death.
• Micafungin (Mycamine) · Astellas Pharma Inc · Infectious Disease
  Micafungin inhibits fungal cell wall synthesis by targeting 1,3-beta-D-glucan synthase, leading to fungal cell death.
• Comparator: Micafungin sodium · Merck Sharp & Dohme LLC · Infectious Disease
  Micafungin sodium inhibits fungal cell wall synthesis by targeting 1,3-beta-D-glucan synthase, leading to fungal cell death.
• Rezafungin for Injection · Mundipharma Research Limited · Infectious Disease
  Rezafungin is an echinocandin antifungal that inhibits fungal cell wall synthesis by targeting 1,3-beta-D-glucan synthase.
• caspofungin antifungal therapy · Centre Hospitalier Universitaire, Amiens · Infectious Diseases
  Caspofungin inhibits the synthesis of beta-1,3-D-glucan, an essential component of fungal cell walls.

Phase 2 pipeline (1)

• Anidulafungin, VER002 · Pfizer · Infectious Disease
  Anidulafungin inhibits fungal cell wall synthesis by targeting β-1,3-glucan synthase, leading to fungal cell death.

Patent intelligence

• echinocandin antifungal patent landscape — aggregated cliff calendar, attackable patents, originator estates