What are Corneal cross-linking agent drugs?

Corneal cross-linking agent drugs are pharmacologic agents that share a common mechanism (typically targeting Corneal collagen (indirect via photochemical cross-linking)). 0 are currently marketed, with 4 more in clinical development.

Corneal cross-linking agent

0 marketed 4 in Phase 3

This page covers all Corneal cross-linking agent drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Corneal collagen (indirect via photochemical cross-linking), Corneal collagen (riboflavin-mediated photochemical cross-linking), Corneal collagen (indirect via riboflavin photosensitization).

Targets

Corneal collagen (indirect via photochemical cross-linking) · Corneal collagen (riboflavin-mediated photochemical cross-linking) · Corneal collagen (indirect via riboflavin photosensitization) · Corneal collagen (photochemical cross-linking via riboflavin and UVA)

Phase 3 pipeline (4)

Riboflavin/Dextran · Cornea and Laser Eye Institute · Ophthalmology
Riboflavin is activated by light to generate reactive oxygen species that cross-link corneal collagen, while dextran acts as an osmotic agent to facilitate corneal hydration during the procedure.
Epi-Off · Icahn School of Medicine at Mount Sinai · Ophthalmology
Epi-Off is a corneal cross-linking procedure that uses riboflavin and ultraviolet-A light to strengthen corneal collagen and halt progression of keratoconus.
Epithelium-Off Riboflavin · Crowd Health Research, LTD · Ophthalmology
Epithelium-off riboflavin uses ultraviolet A light activation of riboflavin to create reactive oxygen species that cross-link corneal collagen, strengthening the cornea.
Epithelium-On Riboflavin · Crowd Health Research, LTD · Ophthalmology
Epithelium-on riboflavin uses riboflavin (vitamin B2) with ultraviolet light exposure to strengthen corneal collagen cross-linking while preserving the corneal epithelium.