What are chemotherapy drugs?

chemotherapy drugs are pharmacologic agents that share a common mechanism (typically targeting DNA replication and repair). 3 are currently marketed, with 28 more in clinical development.

What are the marketed chemotherapy drugs?

Marketed chemotherapy drugs include Folfiri, Folfox-7, irinotecan + Carboplatin + erbitux.

chemotherapy

3 marketed 23 in Phase 3 5 in Phase 2

This page covers all chemotherapy drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting DNA replication and repair, DNA replication machinery, topoisomerase I, platinum DNA damage, epidermal growth factor receptor.

Targets

DNA replication and repair · DNA replication machinery · topoisomerase I, platinum DNA damage, epidermal growth factor receptor · Thymidylate synthase · CD20 · Topoisomerase II, Thymidylate synthase

Marketed (3)

Folfiri · Pfizer · Oncology
Folfox-7 · Pfizer · Oncology
irinotecan + Carboplatin + erbitux · Pfizer · Oncology

Phase 3 pipeline (23)

R-GemOx · Hutchmed · Oncology
R-GemOx is a combination of gemcitabine and oxaliplatin, used to treat various cancers.
UTD1 Injection plus capecitabine · Beijing Biostar Pharmaceuticals Co., Ltd. · Oncology
UTD1 Injection plus capecitabine works by targeting and inhibiting the action of certain enzymes involved in DNA synthesis, thereby inhibiting cancer cell growth.
RCHOP21 · The Lymphoma Academic Research Organisation · Oncology
Rituximab targets and depletes CD20-positive B cells, while cyclophosphamide, doxorubicin, and prednisone work through various mechanisms to induce cell death in cancer cells.
Radiotherapy+PCV chemotherapy · Assistance Publique - Hôpitaux de Paris · Oncology
Radiotherapy works by damaging the DNA of cancer cells, while PCV chemotherapy targets rapidly dividing cells with a combination of drugs.
Taxotere-Cisplatin-5FU · Swiss Cancer Institute · Oncology
Taxotere (docetaxel) works by inhibiting microtubule dynamics, disrupting cell division, and inducing apoptosis in cancer cells. Cisplatin is a platinum-based alkylating agent that cross-links DNA, causing DNA damage and triggering cell death. 5-Fluorouracil (5-FU) is a thymidylate synthase inhibitor that disrupts DNA synthesis and repair.
TPC chemotherapy · Sun Yat-sen University · Oncology
TPC chemotherapy targets rapidly dividing cancer cells by interfering with their DNA replication.
gemcitabine/carboplatin plus Iniparib · Sanofi · Oncology
Gemcitabine and carboplatin work by interfering with DNA replication and cell division, respectively, while iniparib is thought to work by inhibiting PARP enzymes.
long-course chemotherapy · Associazione Italiana per lo Studio del Pancreas · Oncology
Long-course chemotherapy involves administering chemotherapy drugs over an extended period to target and kill cancer cells.
Two cycles of neoadjuvant chemotherapy · Seoul National University Hospital · Oncology
Chemotherapy involves the use of drugs to kill rapidly dividing cancer cells.
TQB2930+ chemotherapy · Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd. · Oncology
TQB2930 is a chemotherapy drug that targets cancer cells.
Standard neoadjuvant therapy · Shanghai Zhongshan Hospital · Oncology
Standard neoadjuvant therapy involves administering a combination of chemotherapy drugs before surgery to reduce tumor size and improve surgical outcomes.
Standard of Care Chemotherapy · Prothena Biosciences Ltd. · Oncology
Standard of Care Chemotherapy works by interfering with the growth of cancer cells, ultimately leading to cell death.
PCV chemotherapy alone · Assistance Publique - Hôpitaux de Paris · Oncology
PCV chemotherapy involves the combination of three chemotherapy drugs: methotrexate, cyclophosphamide, and vincristine, which work together to kill rapidly dividing cancer cells.
Standard adjuvant chemotherapy · University Hospital, Rouen · Oncology
Standard adjuvant chemotherapy involves administering a combination of drugs to kill cancer cells and prevent their return.
standard chemotherapy for colorectal cancer · University Hospital, Rouen · Oncology
Standard chemotherapy for colorectal cancer works by interfering with the growth of cancer cells, ultimately leading to cell death.
cTACE · Chengdu New Radiomedicine Technology Co. LTD. · Oncology
cTACE involves the direct injection of chemotherapy drugs into liver tumors via the hepatic artery.
Utidelone plus Metronomic Capecitabine · Sun Yat-sen University · Oncology
Utidelone is a chemotherapy medication that works by interfering with DNA replication, while metronomic capecitabine is a prodrug that is converted into 5-fluorouracil, which inhibits thymidylate synthase.
neoadjuvant chemotherapyI · Sun Yat-sen University · Oncology
Neoadjuvant chemotherapy involves administering chemotherapy before the main treatment to reduce tumor size and make it easier to remove.
intensive chemotherapy · University Hospital, Toulouse · Oncology
Intensive chemotherapy involves the use of high doses of chemotherapy drugs to kill cancer cells.
parenteral chemotherapy · Warwick Medical School · Oncology
This drug targets cancer cells by inhibiting cell division and inducing apoptosis.
regional chemotherapy · Delcath Systems Inc. · Oncology
Regional chemotherapy involves delivering high doses of chemotherapy directly to a specific area of the body, such as the liver, to treat cancer.
SOC chemotherapy · Ludwig-Maximilians - University of Munich · Oncology
SOC chemotherapy involves administering a combination of chemotherapy drugs to treat cancer.
Physician's choice chemotherapy · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Oncology
Physician's choice chemotherapy involves administering a selection of chemotherapy drugs tailored to the individual patient's needs.

Phase 2 pipeline (5)

Conditioning regimen · Assistance Publique - Hôpitaux de Paris · Oncology
This conditioning regimen involves a combination of chemotherapy and radiation therapy to prepare the body for a bone marrow transplant.
Albumin paclitaxel plus carboplatin · Chinese Society of Lung Cancer · Oncology
Albumin paclitaxel is a formulation of paclitaxel, a microtubule inhibitor, which works by binding to tubulin and preventing the formation of microtubules, thereby inhibiting cell division. Carboplatin is a platinum-based chemotherapy drug that works by cross-linking DNA, thereby inhibiting cell division.
Chemotherapy Doublet · BeiGene · Oncology
Chemotherapy agents work by interfering with DNA replication and cell division, leading to cell death.
Chemotherapy arm B · Prof. Dr. med. Claus Rödel · Oncology
Chemotherapy arm B targets rapidly dividing cancer cells.
GEMOX chemotherapy · Prof. Massimo Aglietta · Oncology
GEMOX chemotherapy combines gemcitabine and oxaliplatin to target rapidly dividing cancer cells.