Last reviewed 2026-04-23 · How we verify

Taxotere-Cisplatin-5FU

Taxotere (docetaxel) works by inhibiting microtubule dynamics, disrupting cell division, and inducing apoptosis in cancer cells. Cisplatin is a platinum-based alkylating agent that cross-links DNA, causing DNA damage and triggering cell death. 5-Fluorouracil (5-FU) is a thymidylate synthase inhibitor that disrupts DNA synthesis and repair.

Taxotere (docetaxel) works by inhibiting microtubule dynamics, disrupting cell division, and inducing apoptosis in cancer cells. Cisplatin is a platinum-based alkylating agent that cross-links DNA, causing DNA damage and triggering cell death. 5-Fluorouracil (5-FU) is a thymidylate synthase inhibitor that disrupts DNA synthesis and repair. Used for Non-small cell lung cancer, Breast cancer, Stomach cancer.

At a glance

Mechanism of action

Taxotere's mechanism of action involves binding to tubulin, preventing microtubule formation and function, which is essential for cell division. Cisplatin forms platinum-DNA adducts, leading to DNA damage and triggering cell death through apoptosis. 5-FU inhibits thymidylate synthase, an enzyme necessary for DNA synthesis and repair, thereby disrupting these processes and inducing cell death.

Approved indications

• Non-small cell lung cancer
• Breast cancer
• Stomach cancer

Common side effects

• Neutropenia
• Nausea and vomiting
• Diarrhea
• Fatigue
• Anemia

Key clinical trials

• NESC: Neoadjuvant Treatment of Gastric Adenocarcinoma (PHASE2)
• tReatment Individualisation By EBV stratificatiON in Nasopharyngeal Carcinoma: an Umbrella Platform Study (RIBBON-Umbrella)
• Combination Chemotherapy and Surgery in Treating Patients With Locally Advanced Stomach Cancer (PHASE3)
• Combination Chemotherapy in Treating Patients With Advanced Stomach Cancer (PHASE2)

Primary sources

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